伊维菌素对培养的鸡脊髓神经元的作用。

The actions of ivermectin on cultured chick spinal cord neurons.

作者信息

Matsumoto K, Yamazaki J, Kasuya M, Fukuda H

出版信息

Neurosci Lett. 1986 Sep 12;69(3):279-84. doi: 10.1016/0304-3940(86)90494-5.

DOI:10.1016/0304-3940(86)90494-5

Abstract

The effects of ivermectin (IVM) on cultured chick spinal neurons sensitive to GABA agonists were investigated. IVM caused a change of membrane potential which was associated with an increase in membrane conductance, apparently reversed at about -40 mV and weakened by repetitive application. Furthermore, this agent did not have any effects on either the actions of GABA agonists on neurons or [3H]GABA efflux from those cells. These results suggest that IVM increases membrane conductance through sites which are different from GABA recognition sites.

摘要

研究了伊维菌素（IVM）对培养的对γ-氨基丁酸（GABA）激动剂敏感的鸡脊髓神经元的影响。IVM引起膜电位变化，这与膜电导增加有关，膜电位变化显然在约-40 mV时逆转，并因重复应用而减弱。此外，该药物对GABA激动剂对神经元的作用或这些细胞中[3H]GABA的流出均无任何影响。这些结果表明，IVM通过与GABA识别位点不同的位点增加膜电导。

相似文献

1

The actions of ivermectin on cultured chick spinal cord neurons.

Neurosci Lett. 1986 Sep 12;69(3):279-84. doi: 10.1016/0304-3940(86)90494-5.

2

Macrolide compounds, ivermectin and milbemycin D, stimulate chloride channels sensitive to GABAergic drugs in cultured chick spinal neurons.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1989;93(1):97-104. doi: 10.1016/0742-8413(89)90017-0.

3

GABA and muscimol open ion channels of different lifetimes on cultured mouse spinal cord cells.

Brain Res. 1981 Jan 5;204(1):242-7. doi: 10.1016/0006-8993(81)90672-7.

4

Analysis of GABA-induced inhibition of spontaneous firing in chick accessory lobe neurons.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2012 Mar;198(3):229-37. doi: 10.1007/s00359-011-0703-0. Epub 2011 Dec 8.

5

[Characteristics of the effect of glycine and gamma-aminobutyric acid on the spinal cord neurons in the lamprey].

Neirofiziologiia. 1988;20(6):823-5.

6

Ethanol potentiates GABA- and glycine-induced chloride currents in chick spinal cord neurons.

Brain Res. 1988 Jul 12;455(2):377-80. doi: 10.1016/0006-8993(88)90098-4.

7

Excitatory and inhibitory actions of GABA and glycine on embryonic chick spinal neurons in culture.

Brain Res. 1978 Apr 7;144(1):179-84. doi: 10.1016/0006-8993(78)90447-x.

8

Non-competitive inhibition of GABA currents by phenothiazines in cultured chick spinal cord and rat hippocampal neurons.

Neurosci Lett. 1988 Sep 23;92(1):86-91. doi: 10.1016/0304-3940(88)90747-1.

9

[Development of sensitivity to glycine, GABA and beta-alanine in cultured spinal neurons].

C R Acad Sci III. 1986;303(4):127-30.

10

Dihydromuscimol, thiomuscimol and related heterocyclic compounds as GABA analogues.

J Neurochem. 1979 Jun;32(6):1717-24. doi: 10.1111/j.1471-4159.1979.tb02284.x.

引用本文的文献

1

Activation of Cl- channels by avermectin in rat cultured hippocampal neurons.

Naunyn Schmiedebergs Arch Pharmacol. 1993 Dec;348(6):628-32. doi: 10.1007/BF00167239.

2

Ivermectin. A review of its antifilarial activity, pharmacokinetic properties and clinical efficacy in onchocerciasis.

Drugs. 1991 Oct;42(4):640-58. doi: 10.2165/00003495-199142040-00007.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。