Kang Xiaoying, Ploner Alexander, Roelstraete Bjorn, Ludvigsson Jonas F, Wirdefeldt Karin
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Neurology, Brigham and Women's Hospital, Boston, MA.
Ann Neurol. 2023 Nov;94(5):911-916. doi: 10.1002/ana.26780. Epub 2023 Sep 7.
Using a population-based matched cohort design, we assessed the association of celiac disease (CeD) with risk of PD by comparing patients with biopsy-confirmed CeD in Sweden to a biopsy-free population and their unaffected siblings, separately. No overall association was observed but CeD diagnosed before age 60 associated positively with incident diagnosis of PD (hazard ratio [HR] = 1.29; 95% confidence interval [CI]: 1.02-1.62), which was mainly attributed to the significantly elevated risk detected after 10-15 years since biopsy (HR = 1.68; 95% CI: 1.05-2.68). Our findings imply an increased vulnerability to long-term PD development among patients with CeD diagnosed before 60s. ANN NEUROL 2023;94:911-916.
采用基于人群的匹配队列设计，我们通过分别比较瑞典经活检确诊为乳糜泻（CeD）的患者与未进行活检的人群及其未患病的兄弟姐妹，评估了CeD与帕金森病（PD）风险之间的关联。未观察到总体关联，但60岁之前诊断出的CeD与PD的发病诊断呈正相关（风险比[HR]=1.29；95%置信区间[CI]：1.02 - 1.62），这主要归因于活检后10 - 15年检测到的风险显著升高（HR = 1.68；95% CI：1.05 - 2.68）。我们的研究结果表明，60岁之前被诊断为CeD的患者患长期PD的易感性增加。《神经病学年鉴》2023年；94卷：911 - 916页
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