游泳时下沉：CCR7 在白细胞迁移中的双重作用。
Sinking while you swim: A dual role for CCR7 in leukocyte migration.
机构信息
School of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, UK.
出版信息
Sci Immunol. 2023 Sep;8(87):eadj3102. doi: 10.1126/sciimmunol.adj3102. Epub 2023 Sep 1.
PMID:37656778
Abstract
The CCR7 receptor allows dendritic cells to sense the chemokine CCL19. It also depletes CCL19 from the environment by endocytosis, leading to local gradients that can steer cells accurately and robustly through tissues, even over long distances (see related Research Article by Alanko .).
摘要
CCR7 受体使树突状细胞能够感知趋化因子 CCL19。它还通过内吞作用从环境中耗尽 CCL19，导致局部梯度，可以准确而有力地引导细胞穿过组织，即使是长距离（见 Alanko 的相关研究文章）。
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