Department of Cardivascular Surgery, University of Health Sciences Trabzon Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, Trabzon, Turkey.
Department of Training Unit, University of Health Sciences Trabzon Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, Trabzon, Turkey.
Medicine (Baltimore). 2023 Sep 1;102(35):e34875. doi: 10.1097/MD.0000000000034875.
Warfarin has a narrow therapeutic window. Maintaining the patient's international normalized ratio (INR) within a predefined therapeutic range is one of the main challenges of warfarin treatment. This study aimed to compare the INR values of patients followed by face-to-face and telephone applications.
This study was designed as a randomized controlled trial. Twelve patients living in a distant place were assigned to the experimental group, and 12 patients living nearby and followed-up in the outpatient clinic were assigned to the control group. A Patient Information Form and the Adherence to Refills and Medications Scale were used to collect data.
There was no significant difference between the groups in terms of demographic and clinical characteristics except for age (P > .05). The INR values of 67% of the patients followed in the outpatient clinic and 72% of the patients followed with the application were in the therapeutic range. There was no significant difference between the groups and medication adherence was high in both groups (P > .05).
In light of the findings of our study, which demonstrated that the INR levels of patients who were monitored both face-to-face and via a telephone application were within the same therapeutic range, it was concluded that the telephone application can be used to manage warfarin therapy.
华法林的治疗窗较窄。将患者的国际标准化比值(INR)维持在预先设定的治疗范围内是华法林治疗的主要挑战之一。本研究旨在比较面对面和电话应用两种随访方式的 INR 值。
本研究设计为随机对照试验。将居住在偏远地区的 12 名患者分配到实验组,将居住在附近并在门诊接受随访的 12 名患者分配到对照组。使用患者信息表和药物依从性量表收集数据。
除年龄外(P>.05),两组在人口统计学和临床特征方面无显著差异。在门诊接受随访的患者中,有 67%的 INR 值处于治疗范围内,通过应用程序接受随访的患者中,有 72%的 INR 值处于治疗范围内。两组之间无显著差异,两组的药物依从性都很高(P>.05)。
根据本研究的结果,即面对面监测和电话应用监测的患者的 INR 水平均处于相同的治疗范围内,可以得出结论,电话应用程序可用于管理华法林治疗。