Zhang Qing, Liang Xiaowen, Zhang Yanfen, Nie Hongjun, Chen Zhiyi
Institution of Medical Imaging, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China; Institution of Medical Imaging, University of South China, Hengyang, China; The Seventh Affiliated Hospital, Hengyang Medical School, University of South China, Changsha, China.
Institution of Medical Imaging, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China; Institution of Medical Imaging, University of South China, Hengyang, China.
Eur J Radiol. 2023 Oct;167:111060. doi: 10.1016/j.ejrad.2023.111060. Epub 2023 Aug 22.
Contrast-enhanced ultrasound (CEUS) is a dependable modality for the diagnosis of various clinical conditions. A judicious selection of ultrasound contrast agent (UCA) is imperative for optimizing imaging and improving diagnosis. Approved UCAs for imaging the majority of organs include SonoVue, a pure blood agent, and Sonazoid, which exhibits an additional Kupffer phase. Despite the fact that the two UCAs are increasingly being employed, there is a lack of comparative reviews between the two agents in different organs diseases. This review represents the first attempt to compare the two UCAs in non-hepatic organs, primarily including breast, thyroid, pancreas, and spleen diseases. Through comparative analysis, this review provides a comprehensive and objective evaluation of the performance characteristics of SonoVue and Sonazoid, with the aim of offering valuable guidance for the clinical application of CEUS. Overall, further clinical evidences are required to compare and contrast the dissimilarities between the two UCAs in non-hepatic organs, enabling clinicians to make an appropriate selection based on actual clinical applications.
超声造影(CEUS)是诊断各种临床病症的可靠方式。明智地选择超声造影剂(UCA)对于优化成像和改善诊断至关重要。用于大多数器官成像的获批UCA包括纯血剂声诺维(SonoVue)和具有额外库普弗相的声诺素(Sonazoid)。尽管这两种UCA的使用越来越多,但在不同器官疾病中,缺乏对这两种造影剂的比较性综述。本综述首次尝试比较这两种UCA在非肝脏器官中的应用,主要包括乳腺、甲状腺、胰腺和脾脏疾病。通过比较分析,本综述对声诺维和声诺素的性能特征进行了全面客观的评估,旨在为CEUS的临床应用提供有价值的指导。总体而言,需要进一步的临床证据来比较和对比这两种UCA在非肝脏器官中的差异,以便临床医生根据实际临床应用做出合适的选择。