Shang Linxiao, Zhong Yuting, Yao Yan, Liu Cun, Wang Lu, Zhang Wenfeng, Liu Jingyang, Wang Xue, Sun Changgang
School of Integrated Traditional Chinese and Western Medicine, Binzhou Medical University, Yantai 264000, China.
College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250022, China.
Biomed Pharmacother. 2023 Oct;166:115414. doi: 10.1016/j.biopha.2023.115414. Epub 2023 Sep 4.
Tumor-associated macrophages (TAMs) are the most critical effector cells of innate immunity and the most abundant tumor-infiltrating immune cells. They play a key role in the clearance of apoptotic bodies, regulation of inflammation, and tissue repair to maintain homeostasis in vivo. With the progression of triple-negative breast cancer（TNBC）, TAMs are "subverted" from tumor-promoting immune cells to tumor-promoting immune suppressor cells, which play a significant role in tumor development and are considered potential targets for cancer therapy. Here, we explored how macrophages, as the most important part of the TNBC ecosystem, are "subverted" to drive cancer evolution and the uniqueness of TAMs in TNBC progression and metastasis. Similarly, we discuss the rationale and available evidence for TAMs as potential targets for TNBC therapy.
肿瘤相关巨噬细胞（TAMs）是固有免疫中最关键的效应细胞，也是肿瘤浸润免疫细胞中数量最多的细胞。它们在清除凋亡小体、调节炎症和组织修复以维持体内稳态方面发挥着关键作用。随着三阴性乳腺癌（TNBC）的进展，TAMs从促肿瘤免疫细胞“转变”为促肿瘤免疫抑制细胞，在肿瘤发展中起重要作用，被认为是癌症治疗的潜在靶点。在此，我们探讨了作为TNBC生态系统最重要组成部分的巨噬细胞如何“转变”以驱动癌症进展，以及TAMs在TNBC进展和转移中的独特性。同样，我们讨论了将TAMs作为TNBC治疗潜在靶点的理论依据和现有证据。
