Bishop M J, Boatman E S, Ivey T D, Jordan J P, Cheney F W
Am Rev Respir Dis. 1986 Oct;134(4):752-6. doi: 10.1164/arrd.1986.134.4.752.
Pulmonary artery obstruction results in minimal parenchymal abnormalities in normal lung and diminishes edema formation in dog lungs injured by oleic acid. We tested the hypothesis that reperfusion of ischemic regions would result in significant injury in normal lung and would ablate the protective effect of ischemia in oleic acid injury. The pulmonary artery of the left diaphragmatic lobe was occluded for 48 h in 12 oleic-acid-injured and 10 normal animals. Observations made immediately before reperfusion and for 4 h after reperfusion in the awake dogs indicated that reperfusion resulted in systemic abnormalities in both groups of animals, including a rise in temperature, a fall in cardiac output, and a marked drop in circulating leukocytes. In uninjured animals, the reperfused lobe demonstrated an elevated wet-to-dry weight ratio of 5.70 +/- 0.13 compared with 4.42 +/- 0.06 for the right diaphragmatic lobe (p less than 0.05). Histologic examination revealed edema and white cell infiltrates in the alveoli of the reperfused lobe in uninjured animals. In injured animals, there was no difference in either wet-to-dry ratios or morphologic aspects between the lobes. The results demonstrate both a local and systemic toxic effect of reperfusion in normal animals and ablation of the partial protective effect of pulmonary artery occlusion in oleic-acid-injured animals.
肺动脉阻塞在正常肺中导致最小的实质异常，并减少油酸损伤的犬肺中的水肿形成。我们测试了这样一个假设，即缺血区域的再灌注会在正常肺中导致显著损伤，并消除缺血对油酸损伤的保护作用。在12只油酸损伤的动物和10只正常动物中，左膈叶的肺动脉被阻塞48小时。在清醒的狗中，在再灌注前和再灌注后4小时进行的观察表明，再灌注在两组动物中均导致全身异常，包括体温升高、心输出量下降和循环白细胞显著减少。在未受伤的动物中，再灌注的肺叶湿重与干重之比升高至5.70±0.13，而右膈叶为4.42±0.06（p<0.05）。组织学检查显示，未受伤动物再灌注肺叶的肺泡中有水肿和白细胞浸润。在受伤的动物中，各肺叶之间的湿重与干重之比或形态学方面均无差异。结果表明，再灌注在正常动物中具有局部和全身毒性作用，并且消除了油酸损伤动物中肺动脉阻塞的部分保护作用。
