用于大鼠正电子发射断层扫描（PET）同步的3D打印双支架系统：设计及其对定量分析的影响

3D-printed dual holder system for simultaneous rat PET scanning: design and influence on quantification.

作者信息

Bouillot Caroline, Daligault Sébastien, Bolbos Radu, Costes Nicolas, Zimmer Luc

机构信息

CERMEP-Imagerie du Vivant, 69 boulevard Pinel, 69003, Lyon, France.

Lyon Neuroscience Research Center (CRNL), INSERM, Université Claude Bernard, Lyon, France.

出版信息

EJNMMI Res. 2023 Sep 7;13(1):80. doi: 10.1186/s13550-023-01027-9.

DOI:10.1186/s13550-023-01027-9

PMID:37676475

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10485197/

Abstract

BACKGROUND

The low throughout of small animal positron emission tomography (PET) images acquisitions represents a substantial limitation. The aims of this study were (i) to design a low-cost support for simultaneous dynamic PET scanning of two lying rats and (ii) to study its impact on brain image quantification.

RESULTS

Accuracy of concentration measurement was 5.5% for one phantom in the field of view, and 5.7% for two phantoms measured simultaneously. Ratio concentration between phantoms showed an error of 6.7% ± 5.1% for Solo upper position, 6.7% ± 3.7% for Solo lower position, 5.9% ± 4.3% for Duo upper position, and 7.4% ± 6% for Duo lower position 6.7% for separated measures, and 6.6% for simultaneous measures. In vivo distribution profiles showed no difference between solo and duo uptakes. Region of Interest quantification in the whole brain showed 4.4% variability solo and 3.5% duo. The quantified test-retest bias was 8% in solo and 5% in duo, and the Intraclass Correlation Coefficient was comparable in solo and duo (0.969 vs. 0.966).

CONCLUSIONS

Our results showed that simultaneous scans of two rats in INVEON do not affect quantification. The dual support system will allow us to reduce protocol costs and duration.

摘要

背景

小动物正电子发射断层扫描（PET）图像采集的低通量是一个重大限制。本研究的目的是：（i）设计一种低成本的支撑装置，用于同时对两只躺卧的大鼠进行动态PET扫描；（ii）研究其对脑图像定量分析的影响。

结果

视野内单个模型浓度测量的准确度为5.5%，同时测量两个模型时为5.7%。模型之间的浓度比显示，单独测量时，上部位置的误差为6.7%±5.1%，下部位置为6.7%±3.7%；同时测量两个模型时，上部位置的误差为5.9%±4.3%，下部位置为7.4%±6%。单独测量时为6.7%，同时测量时为6.6%。体内分布曲线显示单独摄取和同时摄取之间没有差异。全脑感兴趣区的定量分析显示，单独测量时变异性为4.4%，同时测量时为3.5%。定量重测偏差在单独测量时为8%，同时测量时为5%，组内相关系数在单独测量和同时测量时相当（0.969对0.966）。