伴有MYD88 L265P突变及涉及IGHMALT1的t(14;18)(q32;q21)的华氏巨球蛋白血症样B细胞淋巴瘤

Waldenstrom's macroglobulinemia-like B cell lymphoma with MYD88 L265P mutation and t(14;18)(q32;q21) involving IGHMALT1.

作者信息

Furuta Rie, Tatetsu Hiro, Yasunaga Jun-Ichirou, Ueno Mitsunori, Oshiro Kento, Kumanomido Satoshi, Kawano Yawara, Higuchi Yusuke, Honda Yumi, Mikami Yoshiki, Nosaka Kisato, Matsuoka Masao

机构信息

Department of Hematology, Rheumatology and Infectious Diseases, Kumamoto University Hospital, Kumamoto, Japan.

Department of Oncology, Amakusa Central General Hospital, Kumamoto, Japan.

出版信息

Leuk Res Rep. 2023 Aug 28;20:100389. doi: 10.1016/j.lrr.2023.100389. eCollection 2023.

DOI:10.1016/j.lrr.2023.100389

PMID:37693842

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10485152/

Abstract

A 65-year-old woman was referred to the hospital for further investigation of weight loss, hyperproteinemia, and anemia. Serum immunofixation electrophoresis revealed IgM-κ M protein. Bone marrow examination revealed an increase in the number of B -cells with immunoglobulin kappa light-chain restriction. Although the MYD88 L265P mutation was identified in bone marrow mononuclear cells, which suggested the diagnosis of Waldenstrom's macroglobulinemia (WM), a fusion signal of IgH-MALT1, which is commonly observed in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma, was also identified. Here, we describe a rare case of low-grade B-cell lymphoma with MYD88 L265P mutations accompanying IgH-MALT1.

摘要

一名65岁女性因体重减轻、高蛋白血症和贫血被转诊至医院作进一步检查。血清免疫固定电泳显示IgM-κM蛋白。骨髓检查显示B细胞数量增加且存在免疫球蛋白κ轻链限制。虽然在骨髓单个核细胞中检测到MYD88 L265P突变，提示诊断为华氏巨球蛋白血症（WM），但同时也检测到了黏膜相关淋巴组织边缘区淋巴瘤（MALT淋巴瘤）中常见的IgH-MALT1融合信号。在此，我们报告一例罕见的伴有IgH-MALT1的MYD88 L265P突变的低度B细胞淋巴瘤病例。