Department of Epidemiology, School of Public Health, National Vaccine Innovation Platform, Nanjing Medical University, Nanjing, PR China.
Department of Immunization Program, Suzhou Center for Disease Control and Prevention, Suzhou, PR China.
Hum Vaccin Immunother. 2023 Aug 1;19(2):2254965. doi: 10.1080/21645515.2023.2254965.
Children with special health care needs (CSHCNs) are at an increased risk of vaccine-preventable infections (VPDs), but they also face the dilemma of vaccine hesitancy. We obtained information on pediatric visits from the Referral and Assessment Information System for Vaccination (RAISV) and information on vaccination from the Jiangsu Province Immunization Information System (JSIIS). We followed the occurrence of Adverse Events Following Immunization (AEFIs) and VPDs by actively calling and querying the China Information System for Disease Control and Prevention (CISDCP). The Poisson test was used to compare the incidence of AEFIs between groups. A total of 5,037 children who visited a vaccination assessment clinic were followed-up in this study. The majority were children with developmental anomalies (28.5%), certain conditions originating in the perinatal period (12.1%), and nervous system disorders (9.0%). Most CSHCNs (66.9%) were advised to have all vaccines according to routine practice, 29.0% were advised to have partial vaccination, and 4.1% were advised to delay all vaccines and wait for future assessment. A total of 201 (4.0%) CSHCNs were not vaccinated, although they were assessed to be eligible for vaccination. By querying the immunization planning module in CISDCP, we observed 55 AEFI cases, which amounted to an incidence rate of 1.2 per 1,000, and the occurrence of abnormal reactions was not significantly different compared with the general population. The vaccination program following the designed workflow for CSHCNs was safe and could be recommended in other areas.
患有特殊健康需求的儿童(CSHCN)感染疫苗可预防疾病(VPD)的风险增加,但他们也面临疫苗犹豫的困境。我们从疫苗接种转诊和评估信息系统(RAISV)获得儿科就诊信息,从江苏省免疫信息系统(JSIIS)获得疫苗接种信息。我们通过主动电话和查询中国疾病预防控制信息系统(CISDCP)来跟踪疫苗接种后不良反应(AEFI)和 VPD 的发生情况。使用泊松检验比较组间 AEFI 的发生率。本研究共随访了 5037 名到接种评估门诊就诊的儿童。大多数是发育异常的儿童(28.5%)、某些围产期起源的疾病(12.1%)和神经系统疾病(9.0%)。大多数 CSHCN(66.9%)根据常规建议接种所有疫苗,29.0%建议部分接种,4.1%建议推迟所有疫苗并等待未来评估。共有 201 名(4.0%)CSHCN 未接种疫苗,尽管他们被评估为有资格接种疫苗。通过查询 CISDCP 的免疫规划模块,我们观察到 55 例 AEFI 病例,发病率为每 1000 人 1.2 例,与一般人群相比,异常反应的发生没有显著差异。按照设计的 CSHCN 工作流程进行疫苗接种计划是安全的,可以在其他地区推广。