轴手性杂联芳基的对映选择性C-H芳基化反应
Enantioselective C-H Arylation for Axially Chiral Heterobiaryls.
作者信息
Liu Ziyue, Gao Ben, Chernichenko Konstantin, Yang He, Lemaire Sébastien, Tang Wenjun
机构信息
State Key Laboratory of Bio-Organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
School of Chemistry and Material Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, Zhejiang 310024, China.
出版信息
Org Lett. 2023 Sep 29;25(38):7004-7008. doi: 10.1021/acs.orglett.3c02478. Epub 2023 Sep 14.
An enantioselective palladium-catalyzed C-H arylation of functionalized pyrazoles/triazoles/imidazoles is developed, affording a variety of axially chiral -nitro/formyl-substituted heterobiaryls with excellent enantioselectivities and good yields. The method features a deuterated P-chiral phosphorus ligand CD-AntPhos, a broad substrate scope of functionalized heterobiaryls, mild reaction conditions, and low palladium loadings.
开发了一种对映选择性钯催化的官能化吡唑/三唑/咪唑的C-H芳基化反应，可提供各种具有优异对映选择性和良好产率的轴向手性硝基/甲酰基取代的杂联芳基。该方法的特点是使用氘代P-手性磷配体CD-AntPhos，官能化杂联芳基的底物范围广，反应条件温和，钯负载量低。
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