Department of Biology, Indiana University Bloomington, IN 47405-7107, United States.
Department of Biology, Indiana University Bloomington, IN 47405-7107, United States.
Curr Opin Insect Sci. 2023 Dec;60:101114. doi: 10.1016/j.cois.2023.101114. Epub 2023 Sep 13.
Horned beetles have emerged as a powerful study system with which to investigate the developmental mechanisms underlying environment-responsive development and its evolution. We begin by reviewing key advances in our understanding of the diverse roles played by transcription factors, endocrine regulators, and signal transduction pathways in the regulation of horned beetle plasticity. We then explore recent efforts aimed at understanding how such condition-specific expression may be regulated in the first place, as well as how the differential expression of master regulators may instruct conditional expression of downstream target genes. Here, we focus on the significance of chromatin remodeling as a powerful but thus far understudied mechanism able to facilitate trait-, sex-, and species-specific responses to environmental conditions.
角甲虫已成为一个强大的研究系统，可用于研究环境响应发育及其进化的发育机制。我们首先回顾了在转录因子、内分泌调节剂和信号转导途径在调节角甲虫可塑性中的多种作用方面的重要进展。然后，我们探讨了最近在理解如何首先调节这种特定条件下的表达，以及主调控因子的差异表达如何指导下游靶基因的条件表达方面所做的努力。在这里，我们专注于染色质重塑作为一种强大但迄今为止研究不足的机制的意义，这种机制能够促进对环境条件的特征、性别和物种特异性反应。
