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Evaluating the Impact of Orthostatic Syncope and Presyncope on Quality of Life: A Systematic Review and Meta-Analysis.评估直立性晕厥和晕厥前期对生活质量的影响：一项系统评价和荟萃分析。
Front Cardiovasc Med. 2022 Feb 10;9:834879. doi: 10.3389/fcvm.2022.834879. eCollection 2022.
3
Orthostatic Hypotension: Management of a Complex, But Common, Medical Problem.直立性低血压：一种复杂但常见的医学问题的管理。
Circ Arrhythm Electrophysiol. 2022 Mar;15(3):e010573. doi: 10.1161/CIRCEP.121.010573. Epub 2022 Feb 25.
4
The selectivity of α-adrenoceptor agonists for the human α1A, α1B, and α1D-adrenoceptors.α-肾上腺素受体激动剂对人 α1A、α1B 和 α1D-肾上腺素受体的选择性。
Pharmacol Res Perspect. 2021 Aug;9(4):e00799. doi: 10.1002/prp2.799.
5
Orthostatic hypotension in older people: considerations, diagnosis and management.老年人的直立性低血压：考量、诊断与管理
Clin Med (Lond). 2021 May;21(3):e275-e282. doi: 10.7861/clinmed.2020-1044.
6
Alfuzosin for the medical treatment of benign prostatic hyperplasia and lower urinary tract symptoms: a systematic review of the literature and narrative synthesis.阿夫唑嗪用于良性前列腺增生和下尿路症状的医学治疗：文献系统评价与叙述性综合分析
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7
Cardiac Failure Associated with Medical Therapy of Benign Prostatic Hyperplasia: A Population Based Study.良性前列腺增生症的医学治疗相关心力衰竭：一项基于人群的研究。
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良性前列腺增生患者的体位性低血压及其与α-1拮抗剂使用的关联：一项全面的文献综述

Orthostatic Hypotension in Benign Prostatic Hyperplasia Patients and Its Association With Alpha-1 Antagonist Use: A Comprehensive Literature Review.

作者信息

Abubakar Muhammad, Prasad Rachna, Salim Siffat S, Basavaraju Deepak, Khan Munazza, Lateef Ibrahim K, Furqan Ahmad, Raza Saud, Gupta Ishita, Singla Deepak, Adil Hira, Naeem Ather

机构信息

Department of Internal Medicine, Siddique Sadiq Memorial Trust Hospital, Gujranwala, PAK.

Department of Internal Medicine, Ameer-ud-Din Medical College, Lahore General Hospital, Lahore, PAK.

出版信息

Cureus. 2023 Aug 25;15(8):e44097. doi: 10.7759/cureus.44097. eCollection 2023 Aug.

DOI:10.7759/cureus.44097
PMID:37750139
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10518119/
Abstract

Orthostatic hypotension (OH) is frequently observed in benign prostatic hyperplasia (BPH) patients undergoing alpha-1 adrenergic antagonist (A1AA) therapy. While previous studies have acknowledged the prevalence of OH in BPH patients on A1AAs, limited data exist on ranking the safety of different A1AAs. This comprehensive review explores the underlying mechanisms of OH, examines numerous factors influencing its development, and provides insights into effective treatment strategies such as hydration, gradual postural changes, leg exercises, compression stockings, and tilt-table training for BPH management. The review highlights the significance of individualized care, interdisciplinary collaboration, and further research to optimize A1AA treatment, improve patient outcomes, and enhance quality of life.

摘要

体位性低血压（OH）在接受α-1肾上腺素能拮抗剂（A1AA）治疗的良性前列腺增生（BPH）患者中经常出现。虽然先前的研究已经认识到接受A1AA治疗的BPH患者中OH的患病率，但关于不同A1AA安全性排名的数据有限。这篇综述探讨了OH的潜在机制，研究了影响其发生发展的众多因素，并为BPH管理提供了有效的治疗策略见解，如补液、逐渐改变体位、腿部锻炼、穿弹力袜和倾斜台训练。该综述强调了个性化护理、跨学科合作以及进一步研究以优化A1AA治疗、改善患者预后和提高生活质量的重要性。