Parks Robbie M, Rowland Sebastian T, Do Vivian, Boehme Amelia K, Dominici Francesca, Hart Carl L, Kioumourtzoglou Marianthi-Anna
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
The Earth Institute, Columbia University, New York, NY, USA.
Commun Med (Lond). 2023 Sep 26;3(1):118. doi: 10.1038/s43856-023-00346-1.
Limited evidence exists on how temperature increases are associated with hospital visits from alcohol- and substance-related disorders, despite plausible behavioral and physiological pathways.
In the present study, we implemented a case-crossover design, which controls for seasonal patterns, long-term trends, and non- or slowly-varying confounders, with distributed lag non-linear temperature terms (0-6 days) to estimate associations between daily ZIP Code-level temperature and alcohol- and substance-related disorder hospital visit rates in New York State during 1995-2014. We also examined four substance-related disorder sub-causes (cannabis, cocaine, opioid, sedatives).
Here we show that, for alcohol-related disorders, a daily increase in temperature from the daily minimum (-30.1 °C (-22.2 °F)) to the 75th percentile (18.8 °C (65.8 °F)) across 0-6 lag days is associated with a cumulative 24.6% (95%CI,14.6%-34.6%) increase in hospital visit rates, largely driven by increases on the day of and day before hospital visit, with an association larger outside New York City. For substance-related disorders, we find evidence of a positive association at temperatures from the daily minimum (-30.1 °C (-22.2 °F)) to the 50th percentile (10.4 °C (50.7 °F)) (37.7% (95%CI,27.2%-48.2%), but not at higher temperatures. Findings are consistent across age group, sex, and social vulnerability.
Our work highlights how hospital visits from alcohol- and substance-related disorders are currently impacted by elevated temperatures and could be further affected by rising temperatures resulting from climate change. Enhanced social infrastructure and health system interventions could mitigate these impacts.
尽管存在合理的行为和生理途径,但关于气温升高与酒精及物质相关障碍导致的住院就诊之间的关联,现有证据有限。
在本研究中,我们采用了病例交叉设计,该设计可控制季节模式、长期趋势以及非时变或缓慢变化的混杂因素,并使用分布滞后非线性温度项(0 - 6天)来估计1995 - 2014年纽约州每日邮政编码区域层面的温度与酒精及物质相关障碍住院就诊率之间的关联。我们还研究了四种物质相关障碍的子病因(大麻、可卡因、阿片类药物、镇静剂)。
我们发现,对于酒精相关障碍,在0 - 6天的滞后天数内,每日温度从每日最低温度(-30.1°C(-22.2°F))升至第75百分位数(18.8°C(65.8°F)),与住院就诊率累计增加24.6%(95%置信区间,14.6% - 34.6%)相关,这主要是由就诊当天及前一天的增加所驱动,在纽约市以外地区这种关联更大。对于物质相关障碍,我们发现在温度从每日最低温度(-30.1°C(-22.2°F))升至第50百分位数(10.4°C(50.7°F))时存在正相关(37.7%(95%置信区间,27.2% - 48.2%)),但在更高温度下则不存在。研究结果在年龄组、性别和社会脆弱性方面是一致的。
我们的研究强调了当前酒精及物质相关障碍导致的住院就诊如何受到气温升高的影响,以及可能会因气候变化导致的气温上升而受到进一步影响。加强社会基础设施和卫生系统干预措施可以减轻这些影响。