Cucoranu Dragoș Constantin, Pop Marian, Niculescu Raluca, Kosovski Irina-Bianca, Toganel Radu-Ovidiu, Licu Razvan-Andrei, Bacârea Anca
Department of Radiology, Mures County Emergency Hospital, 540136 Targu Mures, Romania.
ME1 Department, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.
Curr Health Sci J. 2023 Apr-Jun;49(2):244-250. doi: 10.12865/CHSJ.49.02.244. Epub 2023 Jun 30.
Concerns about how non-alcoholic fatty liver disease (NAFLD) might contribute to the development of cardiovascular disease (CVD) have grown as the importance of NAFLD and its relationship to the metabolic syndrome has grown. The purpose of this cross-sectional retrospective is to investigate potential correlations between hepatic steatosis in liver segments seen when measuring calcium score and the presence of atherosclerotic CAD (coronary artery disease).
Two hundred patients (mean age, 57 years±10) who underwent coronary cardiac computed tomography (CT) scans were included. CT scans were analysed to assess the attenuation of liver parenchyma and the coronary artery calcification (CAC).
Age, gender, body mass index (BMI) and CAC score were significantly associated with hepatic steatosis. Among all patients, CAC score (r=-0.31, p<0.0001), and BMI (r=-0.40, p<0.0001) had a moderate negative correlation with the values of liver attenuation. BMI (OR: 1.109, p=0.001), CAC score (OR: 1.629, p<0.001), and age (OR: 1.050, p<0.001) were found to be independent predictors of hepatic steatosis through logistic regression.
A statistically significant correlation between CAC score and the presence of NAFLD as evaluated by non-contrast-enhanced CT was demonstrated. BMI, CAC score, and age were identified as independent predictors of hepatic steatosis.
随着非酒精性脂肪性肝病（NAFLD）的重要性及其与代谢综合征的关系日益凸显，人们越来越关注NAFLD如何可能导致心血管疾病（CVD）的发生。本横断面回顾性研究的目的是调查在测量钙化积分时肝脏各段肝脂肪变性与动脉粥样硬化性冠心病（CAD）存在之间的潜在相关性。
纳入200例接受冠状动脉计算机断层扫描（CT）的患者（平均年龄57岁±10岁）。分析CT扫描以评估肝实质的衰减和冠状动脉钙化（CAC）情况。
年龄、性别、体重指数（BMI）和CAC积分与肝脂肪变性显著相关。在所有患者中，CAC积分（r=-0.31，p<0.0001）和BMI（r=-0.40，p<0.0001）与肝脏衰减值呈中度负相关。通过逻辑回归发现，BMI（比值比：1.109，p=0.001）、CAC积分（比值比：1.629，p<0.001）和年龄（比值比：1.050，p<0.001）是肝脂肪变性的独立预测因素。
通过非增强CT评估，证实了CAC积分与NAFLD存在之间具有统计学显著相关性。BMI、CAC积分和年龄被确定为肝脂肪变性的独立预测因素。
