一名HIV感染患者因播散性组织胞浆菌病导致噬血细胞性淋巴组织细胞增生症。
Hemophagocytic Lymphohistiocytosis due to Disseminated Histoplasmosis in a Patient with HIV Infection.
作者信息
Divyashree Krishna, Singh Harpreet, Parkhi Mayur, Karmakar Indrani, Sachdeva Man Updesh Singh, Suri Vikas, Bhalla Ashish
机构信息
Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
J Glob Infect Dis. 2023 Aug 11;15(3):124-126. doi: 10.4103/jgid.jgid_190_22. eCollection 2023 Jul-Sep.
Hemophagocytic lymphohistiocytosis is usually considered a rapidly progressive fatal illness with poor outcomes. It is of two types: primary or familial and secondary. In patients with HIV, opportunistic infections are the secondary triggers of HLH. First line of management of infection associated HLH is treatment of the underlying infection. Here, we present a case of HLH in HIV infection due to disseminated histoplasmosis managed with liposomal amphotericin B, who required immunosuppressive therapy with intravenous immunoglobulin and dexamethasone due to nonresponse to primary therapy.
噬血细胞性淋巴组织细胞增生症通常被认为是一种进展迅速的致命疾病，预后较差。它有两种类型：原发性或家族性以及继发性。在艾滋病病毒感染者中，机会性感染是噬血细胞性淋巴组织细胞增生症的继发性触发因素。感染相关性噬血细胞性淋巴组织细胞增生症的一线治疗是治疗潜在感染。在此，我们报告一例因播散性组织胞浆菌病导致的艾滋病病毒感染相关性噬血细胞性淋巴组织细胞增生症病例，该患者接受脂质体两性霉素B治疗，因对初始治疗无反应而需要静脉注射免疫球蛋白和地塞米松进行免疫抑制治疗。
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