肺炎疫苗接种可能为阿尔茨海默病提供针对特定基因型的保护。
Vaccination Against Pneumonia May Provide Genotype-Specific Protection Against Alzheimer's Disease.
机构信息
Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA.
Department of Foundational Sciences and Humanities, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
出版信息
J Alzheimers Dis. 2023;96(2):499-505. doi: 10.3233/JAD-230088.
Abstract
Vaccine repurposing that considers individual genotype may aid personalized prevention of Alzheimer's disease (AD). In this retrospective cohort study, we used Cardiovascular Health Study data to estimate associations of pneumococcal polysaccharide vaccine and flu shots received between ages 65-75 with AD onset at age 75 or older, taking into account rs6859 polymorphism in NECTIN2 gene (AD risk factor). Pneumococcal vaccine, and total count of vaccinations against pneumonia and flu, were associated with lower odds of AD in carriers of rs6859 A allele, but not in non-carriers. We conclude that pneumococcal polysaccharide vaccine is a promising candidate for genotype-tailored AD prevention.
摘要
疫苗的重新利用，如果考虑到个体基因型，可能有助于阿尔茨海默病（AD）的个性化预防。在这项回顾性队列研究中，我们使用心血管健康研究的数据来估计肺炎球菌多糖疫苗和流感疫苗在 65-75 岁之间接种与 75 岁或以上 AD 发病的相关性，同时考虑到 NECTIN2 基因（AD 风险因素）rs6859 多态性。肺炎球菌疫苗以及针对肺炎和流感的总疫苗接种次数与 rs6859 A 等位基因携带者的 AD 发病几率降低相关，但与非携带者无关。我们的结论是，肺炎球菌多糖疫苗是一种有前途的针对特定基因型的 AD 预防候选疫苗。
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