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使用蒙特卡罗模拟和实验测量优化 Eclipse TPS 束流配置参数进行小场剂量学。

Optimization of the Eclipse TPS beam configuration parameters for small field dosimetry using Monte Carlo simulations and experimental measurements.

机构信息

Department of Medical Physics, Institut Claudius Regaud - Institut Universitaire du Cancer de Toulouse Oncopole, 1 avenue Irène Joliot Curie, 31059 Toulouse Cedex 9, France; Centre de Recherche et de Cancérologie de Toulouse, UMR1037 INSERM - Université Toulouse 3 - ERL5294 CNRS, 2 avenue Hubert Curien, 31037 Toulouse Cedex 1, France; Laboratoire de "Mathématiques et Applications", Unité de recherche "Mathématiques et Modélisation", Centre d'analyses et de recherche, Faculté des sciences, Université Saint-Joseph, Beyrouth 1104 2020, Lebanon.

Centre de Recherche et de Cancérologie de Toulouse, UMR1037 INSERM - Université Toulouse 3 - ERL5294 CNRS, 2 avenue Hubert Curien, 31037 Toulouse Cedex 1, France.

出版信息

Phys Med. 2023 Oct;114:103141. doi: 10.1016/j.ejmp.2023.103141. Epub 2023 Oct 30.

Abstract

PURPOSE

To evaluate the impact of tuning the beam configurations parameters on the Analytical Anisotropic Algorithm (AAA) and the Acuros XB (AXB) algorithm for small fields using Monte Carlo simulations and measurements.

METHODS

The TrueBeam STx with the high-definition 120 multi-leaf collimator (HD120-MLC) was modeled with Geant4 application for emission tomography (GATE) Monte Carlo platform and validated against measurements. The impact of varying the effective spot size (ESS) and dosimetric leaf gap (DLG) on AAA and AXB calculations was carried out for small MLC-fields ranging from 0.5×0.5 cm to 3 × 3 cm. Beam penumbras, field sizes and output factors calculated by AAA and AXB were compared to GATE calculations and measurements.

RESULTS

The beam penumbra comparisons showed that the best ESS value for AXB was about 1.0 mm in the crossplane direction and 0.5 mm in the inplane direction. By optimizing the ESS values, AXB could provide output factor results almost within 2% of GATE calculations and measurements for fields down to 0.5×0.5 cm. For AAA, significant output factor differences were observed for all ESS values and tuning the DLG in addition to the ESS optimization resulted in an absorbed dose difference of less than 2.5% for MLC-fields down to 1 × 1 cm.

CONCLUSION

By optimizing the ESS values, AXB can achieve accurate output factors in the case of small MLC-fields without the need of DLG tuning. Nevertheless, compromises between the output factor, DLG and ESS values were found necessary for AAA calculations. A MLC model improvement would allow to avoid the complexity related to tuning the configuration parameters.

摘要

目的

通过蒙特卡罗模拟和测量评估调整束流配置参数对小野 AAA 分析各向异性算法和 Acuros XB(AXB)算法的影响。

方法

使用 GATE 蒙特卡罗平台的 Geant4 应用程序(GATE)对配有高清 120 多叶准直器(HD120-MLC)的 TrueBeam STx 进行建模,并与测量结果进行验证。针对 0.5×0.5cm 至 3×3cm 的小 MLC 野,研究了有效射野尺寸(ESS)和剂量学叶片间隙(DLG)变化对 AAA 和 AXB 计算的影响。通过 AAA 和 AXB 计算的束流半影、射野大小和输出因子与 GATE 计算和测量结果进行了比较。

结果

束流半影比较表明,AXB 在横平面方向的最佳 ESS 值约为 1.0mm,在平面内方向的最佳 ESS 值约为 0.5mm。通过优化 ESS 值,AXB 可以为小至 0.5×0.5cm 的射野提供几乎在 2%以内的与 GATE 计算和测量结果相符的输出因子结果。对于 AAA,对于所有 ESS 值,都观察到明显的输出因子差异,并且除了优化 ESS 之外,还调整 DLG 会导致 MLC 野低至 1×1cm 时吸收剂量的差异小于 2.5%。

结论

通过优化 ESS 值,AXB 可以在无需调整 DLG 的情况下实现小 MLC 野的准确输出因子。然而,AAA 计算需要在输出因子、DLG 和 ESS 值之间进行权衡。对多叶准直器模型进行改进,可以避免与调整配置参数相关的复杂性。

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