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[肝硬化]

[Liver Cirrhosis].

作者信息

Brenig Robert, Bernsmeier Christine

机构信息

Innere Medizin, Universitätsspital Basel, Basel, Schweiz.

Department of Biomedicine, University of Basel, Basel, Schweiz.

出版信息

Praxis (Bern 1994). 2023 Sep;112(11):554-561.

Abstract

Cirrhosis is a common disease with high morbidity and mortality. In industrialised countries, the most common causes of cirrhosis are the alcoholic liver disease, non-alcoholic fatty liver disease and chronic viral hepatitis. Cirrhosis is often diagnosed late, as it can be asymptomatic for a long time. Therefore, hepatopathy screening in high-risk patients and fibrosis surveillance using the ultrasound, in the presence of a chronic hepatopathy are essential. A liver biopsy is necessary to confirm the diagnosis. With optimal therapy, in some cases, cirrhosis is preventable and potentially reversible in others. In the stage of decompensation, typically characterised by ascites, patients often die from recurrent infections or hepatocellular carcinoma unless cured by liver transplantation. The prevention and treatment of complications as well as the evaluation of a transplant require cooperation with a centre hospital.

摘要

肝硬化是一种发病率和死亡率都很高的常见疾病。在工业化国家,肝硬化最常见的病因是酒精性肝病、非酒精性脂肪性肝病和慢性病毒性肝炎。肝硬化常常在晚期才被诊断出来,因为它可能长时间没有症状。因此,对高危患者进行肝病筛查以及在存在慢性肝病的情况下使用超声进行纤维化监测至关重要。确诊需要进行肝活检。通过最佳治疗,在某些情况下,肝硬化是可以预防的,在其他情况下则可能是可逆的。在失代偿期,通常以腹水为特征,患者常常死于反复感染或肝细胞癌,除非通过肝移植治愈。并发症的预防和治疗以及移植评估需要与中心医院合作。

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