Ghosh Ankita, Horn Paul S, Kabbouche Samaha Marielle, Kacperski Joanne, LeCates Susan L, White Shannon, Powers Scott W, Hershey Andrew D
Division of Neurology (AG), Le Bonheur Children's Hospital, Memphis, TN; Division of Neurology (AG, PSH, MKS, JK, SLL, SW, ADH), Cincinnati Children's Hospital; Department of Pediatrics (PSH, MKS, JK, SWP, ADH), University of Cincinnati College of Medicine; and Division of Behavioral Medicine and Clinical Psychology (SWP), Cincinnati Children's Hospital Medical Center, OH.
Neurol Clin Pract. 2023 Oct;13(5):e200188. doi: 10.1212/CPJ.0000000000200188. Epub 2023 Aug 17.
The prevalence of generalized joint hypermobility (GJH) is 5-65% in children and adolescents. The hypothesis of this study was to see whether there is an association between headache characteristics and GJH in children and adolescents with migraine.
We performed a primary retrospective case-control analysis of an established database of patients with headache aged 5-17 years.
We included 5435 participants. Approximately 31.6% of participants (1,719/5,435) were diagnosed with GJH (Beighton score ≥ 6). Nausea (73.1% vs 67.5%, χ with 1 degree of freedom = 17.0, < 0.0001), phonophobia (87.3% vs 78.8%, χ with 1 degree of freedom = 18.0, < 0.0001), and the PedMIDAS score (48.2 ± 52.5, 95% CI 45.7-50.6 vs 41.6 ± 51.2, 95% CI 40.0-43.3, effect size = 0.13, < 0.0001) were noted to be more severe in participants with GJH than those without GJH.
Youths with GJH and migraine were noted to have more severe migraine characteristics.
儿童和青少年中全身关节活动过度(GJH)的患病率为5%-65%。本研究的假设是,偏头痛的儿童和青少年中,头痛特征与GJH之间是否存在关联。
我们对一个已建立的5-17岁头痛患者数据库进行了初步回顾性病例对照分析。
我们纳入了5435名参与者。约31.6%的参与者(1719/5435)被诊断为GJH(Beighton评分≥6)。有GJH的参与者的恶心症状(73.1%对67.5%,自由度为1的卡方检验=17.0,P<0.0001)、恐声症(87.3%对78.8%,自由度为1的卡方检验=18.0,P<0.0001)和儿童偏头痛残疾评估量表(PedMIDAS)评分(48.2±52.5,95%置信区间45.7-50.6对41.6±51.2,95%置信区间40.0-43.3,效应量=0.13,P<0.0001)比无GJH的参与者更严重。
GJH和偏头痛的青少年偏头痛特征更严重。