Department of Ophthalmology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Department of Cardiothoracic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Eur J Ophthalmol. 2024 May;34(3):708-718. doi: 10.1177/11206721231208244. Epub 2023 Oct 23.
Emerging evidence suggested a significant association between optic atrophy 1 (OPA1) polymorphisms and primary open angle glaucoma (POAG) risk. However, the current data are inconsistent or even contradictory. Given these, we conducted a meta-analysis to examine the precise association between OPA1 polymorphisms and POAG risk.
Online databases were retrieved, and the related studies were reviewed from inception to December 1, 2022. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated to examine the statistical power of each genetic model. In addition, heterogeneity, sensitivity, cumulative analysis, and publication bias were analyzed to guarantee statistical power.
Overall, 14 studies within 11 publications (involving 2,413 POAG patients and 1,904 controls) were included and some significant association between OPA1 rs166850 C/T (T vs. C: OR = 1.24, 95%CI = 1.06-1.45, = 0.01, I= 39.0%; CT vs. CC: OR = 1.37, 95%CI = 1.05-1.79, = 0.02, I= 41.6%; CT + TT vs. CC: 1.37, 95%CI = 1.06-1.77, = 0.02, I= 41.6%), rs10451941T/C (TC + CC vs. TT: OR = 1.79, 95%CI = 1.41-2.28, < 0.01, I= 71.9%) polymorphisms and POAG susceptibility. In addition, further significant associations were also observed in the stratified analysis, especially in normal tension glaucoma groups and Caucasian descendants.
The observed evidences suggest that OPA1 polymorphisms may be associate with POAG susceptibility significantly.
新出现的证据表明，视萎缩 1 （OPA1）多态性与原发性开角型青光眼（POAG）风险之间存在显著关联。然而，目前的数据不一致甚至相互矛盾。鉴于此，我们进行了一项荟萃分析，以检验 OPA1 多态性与 POAG 风险之间的确切关联。
在线数据库被检索，从成立到 2022 年 12 月 1 日，对相关研究进行了回顾。使用优势比（OR）和相应的 95%置信区间（CI）来计算每个遗传模型的统计学功效。此外，还分析了异质性、敏感性、累积分析和发表偏倚，以保证统计学功效。
总体而言，纳入了 11 篇文献中的 14 项研究（涉及 2413 名 POAG 患者和 1904 名对照），发现 OPA1 rs166850 C/T（T 对 C：OR=1.24，95%CI=1.06-1.45，P=0.01，I=39.0%；CT 对 CC：OR=1.37，95%CI=1.05-1.79，P=0.02，I=41.6%；CT+TT 对 CC：OR=1.37，95%CI=1.06-1.77，P=0.02，I=41.6%）和 rs10451941T/C（TC+CC 对 TT：OR=1.79，95%CI=1.41-2.28，P<0.01，I=71.9%）多态性与 POAG 易感性显著相关。此外，在分层分析中也观察到了进一步的显著关联，尤其是在正常眼压性青光眼组和白种人后裔中。
观察到的证据表明，OPA1 多态性可能与 POAG 易感性显著相关。
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