Venigalla Greeshma, Ila Vishal, Dornbush James, Bernstein Ari, Loloi Justin, Pozzi Edoardo, Miller David, Ramasamy Ranjith
Desai Sethi Urology Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Medical College of Georgia, AU/UGA Medical Partnership, Augusta, Georgia, USA.
Andrology. 2025 Jan;13(1):64-71. doi: 10.1111/andr.13552. Epub 2023 Oct 26.
Obesity rates are increasing globally, making it imperative to comprehend the effects of parental obesity on human reproduction. This review aims to highlight the impact of male obesity on reproductive and offspring outcomes. Male obesity has been shown to affect fertility through various mechanisms, including changes in semen quality, difficulty with natural conception, and worsened assisted reproductive technology outcomes. The evidence regarding the impact of male obesity on success of sperm retrieval is conflicting, but all aforementioned adverse effects may be modifiable with weight loss. Moreover, paternal obesity may influence atypical offspring outcomes, such as placental abnormalities and disruptions in fetal development, which may be moderated by epigenetic pathways. Further research is needed to fully understand the complex relationships and underlying mechanisms involved. Gaining more insight into the impact of male obesity on fertility and offspring outcomes can aid in the development of targeted interventions to improve family planning and the health of future generations.
全球肥胖率正在上升，因此必须了解父母肥胖对人类生殖的影响。本综述旨在强调男性肥胖对生殖及后代结局的影响。已表明男性肥胖会通过多种机制影响生育能力，包括精液质量变化、自然受孕困难以及辅助生殖技术结局恶化。关于男性肥胖对取精成功率影响的证据存在矛盾，但上述所有不良影响都可能通过减肥得到改善。此外，父亲肥胖可能会影响非典型的后代结局，如胎盘异常和胎儿发育紊乱，而这些可能会通过表观遗传途径得到缓解。需要进一步研究以充分理解其中涉及的复杂关系和潜在机制。深入了解男性肥胖对生育能力和后代结局的影响有助于制定有针对性的干预措施，以改善计划生育并促进后代健康。
