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肠道微生物群和代谢物及其在合并心力衰竭和抑郁症状中的相互作用的景观：随机森林分析研究。

Landscape of gut microbiota and metabolites and their interaction in comorbid heart failure and depressive symptoms: a random forest analysis study.

机构信息

Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, China.

Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China.

出版信息

mSystems. 2023 Dec 21;8(6):e0051523. doi: 10.1128/msystems.00515-23. Epub 2023 Oct 26.

DOI:10.1128/msystems.00515-23
PMID:37882579
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10734515/
Abstract

There is increasing evidence that alterations in gut microbial composition and function are associated with cardiovascular or psychiatric disease. Therefore, it is meaningful to investigate the taxonomic and functional characterization of the microbiota in HF patients who also have depressive symptoms. In this cross-sectional study, and alpha-tocopherol were determined as new diagnostic markers. Furthermore, intestinal microecosystem disorders are closely linked to depressive symptoms in HF patients, providing a new reference viewpoint for understanding the gut-heart/brain axis.

摘要

越来越多的证据表明，肠道微生物组成和功能的改变与心血管或精神疾病有关。因此，研究同时患有抑郁症状的心力衰竭患者的微生物群落的分类和功能特征是有意义的。在这项横断面研究中，和α-生育酚被确定为新的诊断标志物。此外，肠道微生态系统紊乱与心力衰竭患者的抑郁症状密切相关，为理解肠道-心脏/大脑轴提供了新的参考观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95dd/10734515/667b8239ae93/msystems.00515-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95dd/10734515/5af3dd8fee69/msystems.00515-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95dd/10734515/20f6da17c7c3/msystems.00515-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95dd/10734515/e452d7fb7fec/msystems.00515-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95dd/10734515/488444e331b0/msystems.00515-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95dd/10734515/667b8239ae93/msystems.00515-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95dd/10734515/5af3dd8fee69/msystems.00515-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95dd/10734515/20f6da17c7c3/msystems.00515-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95dd/10734515/e452d7fb7fec/msystems.00515-23.f003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95dd/10734515/667b8239ae93/msystems.00515-23.f005.jpg

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Front Psychiatry. 2022 Jul 19;13:902433. doi: 10.3389/fpsyt.2022.902433. eCollection 2022.
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Bacterial Butyrate in Parkinson's Disease Is Linked to Epigenetic Changes and Depressive Symptoms.帕金森病中的细菌丁酸与表观遗传改变和抑郁症状有关。
Mov Disord. 2022 Aug;37(8):1644-1653. doi: 10.1002/mds.29128. Epub 2022 Jun 20.
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A metabolic axis in obesity and type 2 diabetes.肥胖和 2 型糖尿病中的代谢轴。
心血管疾病与抑郁症：一项荟萃分析和孟德尔随机化分析
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