三维磁共振指纹技术定量膝关节软骨 T1、T2 和 T2* 值的可重复性。

Repeatability of Quantitative Knee Cartilage T, T, and T Mapping With 3D-MRI Fingerprinting.

机构信息

Center of Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.

出版信息

J Magn Reson Imaging. 2024 Aug;60(2):688-699. doi: 10.1002/jmri.29068. Epub 2023 Oct 26.

DOI:10.1002/jmri.29068

PMID:37885320

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11045656/

Abstract

BACKGROUND

Three-dimensional MR fingerprinting (3D-MRF) techniques have been recently described for simultaneous multiparametric mapping of knee cartilage. However, investigation of repeatability remains limited.

PURPOSE

To assess the intra-day and inter-day repeatabilities of knee cartilage T, T, and T maps using a 3D-MRF sequence for simultaneous measurement.

STUDY TYPE

Prospective.

SUBJECTS

Fourteen healthy subjects (35.4 ± 9.3 years, eight males), scanned on Day 1 and Day 7.

FIELD STRENGTH/SEQUENCE: 3 T/3D-MRF, T, T, and T maps.

ASSESSMENT

The acquisition of 3D-MRF cartilage (simultaneous acquisition of T, T, and T maps) were acquired using a dictionary pattern-matching approach. Conventional cartilage T, T, and T maps were acquired using variable flip angles and a modified 3D-Turbo-Flash sequence with different echo and spin-lock times, respectively, and were fitted using mono-exponential models. Each sequence was acquired on Day 1 and Day 7 with two scans on each day.

STATISTICAL TESTS

The mean and SD for cartilage T, T, and T were calculated in five manually segmented regions of interest (ROIs), including lateral femur, lateral tibia, medial femur, medial tibia, and patella cartilages. Intra-subject and inter-subject repeatabilities were assessed using coefficient of variation (CV) and intra-class correlation coefficient (ICC), respectively, on the same day and among different days. Regression and Bland-Altman analysis were performed to compare maps between the conventional and 3D-MRF sequences.

RESULTS

The CV in all ROIs was lower than 7.4%, 8.4%, and 7.5% and the ICC was higher than 0.56, 0.51, and 0.52 for cartilage T, T, and T, respectively. The MRF results had a good agreement with the conventional methods with a linear regression slope >0.61 and R > 0.59.

CONCLUSION

The 3D-MRF sequence had high intra-subject and inter-subject repeatabilities for simultaneously measuring knee cartilage T, T, and T with good agreement with conventional sequences.

EVIDENCE LEVEL

1 TECHNICAL EFFICACY: Stage 1.

摘要

背景

最近已经描述了三维磁共振指纹成像（3D-MRF）技术，用于同时对膝关节软骨进行多参数映射。然而，对重复性的研究仍然有限。

目的

使用 3D-MRF 序列同时测量评估膝关节软骨 T1、T2 和 T2*地图的日内和日间重复性。

研究类型

前瞻性。

受试者

14 名健康受试者（35.4±9.3 岁，8 名男性），于第 1 天和第 7 天进行扫描。

磁场强度/序列：3T/3D-MRF、T1、T2 和 T2*地图。

评估

通过字典模式匹配方法获得 3D-MRF 软骨（同时获得 T1、T2 和 T2地图）的采集。使用可变翻转角和修改后的 3D-Turbo-Flash 序列分别获得常规软骨 T1、T2 和 T2地图，并且使用单指数模型进行拟合。第 1 天和第 7 天每天进行两次扫描，分别采集每个序列。

统计学检验

在五个手动分割的感兴趣区（ROI）中计算软骨 T1、T2 和 T2*的平均值和标准差，包括外侧股骨、外侧胫骨、内侧股骨、内侧胫骨和髌骨软骨。在同一天和不同天分别使用变异系数（CV）和组内相关系数（ICC）评估受试者内和受试者间的重复性。进行回归和 Bland-Altman 分析以比较常规和 3D-MRF 序列之间的地图。