牛磺酸对慢性充血性心力衰竭家兔的有益作用。

Beneficial effect of taurine in rabbits with chronic congestive heart failure.

作者信息

Takihara K, Azuma J, Awata N, Ohta H, Hamaguchi T, Sawamura A, Tanaka Y, Kishimoto S, Sperelakis N

出版信息

Am Heart J. 1986 Dec;112(6):1278-84. doi: 10.1016/0002-8703(86)90360-1.

Abstract

To examine the effect of daily treatment with taurine on improving the status of congestive heart failure (CHF), we used rabbits with artificially induced aortic regurgitation. Ten rabbits were treated daily with taurine (100 mg/kg by mouth) and eight with guanidinoethyl sulfonate (GES) (100 mg/kg by mouth) immediately after induction of aortic regurgitation. The cumulative mortality rate at 8 weeks in the taurine-treated CHF group was 10% (1 of 10) compared with 53% (16 of 30) in the nontreated CHF group and 75% (6 of 8) in the GES-treated CHF group (p less than 0.05). Although cardiac function (max dP/dt) in CHF rabbits was significantly decreased (p less than 0.001), taurine-treated CHF rabbits maintained the same values as control rabbits. Taurine content of the left ventricular tissue of the CHF rabbits was significantly increased (p less than 0.01). Administration of taurine and GES to control rabbits for 8 weeks affected neither the hemodynamics nor the taurine content of the heart. It was concluded that taurine slowed the rapid progression of heart failure and consequently prolonged life expectancy.

摘要

为研究牛磺酸每日治疗对改善充血性心力衰竭（CHF）状态的影响，我们使用了人工诱导主动脉反流的兔子。在诱导主动脉反流后，立即对10只兔子每日给予牛磺酸（经口100mg/kg），对8只兔子每日给予胍基乙磺酸（GES）（经口100mg/kg）。牛磺酸治疗的CHF组8周时的累积死亡率为10%（10只中的1只），而未治疗的CHF组为53%（30只中的16只），GES治疗的CHF组为75%（8只中的6只）（p<0.05）。尽管CHF兔子的心脏功能（最大dP/dt）显著降低（p<0.001），但牛磺酸治疗的CHF兔子维持了与对照兔子相同的值。CHF兔子左心室组织中的牛磺酸含量显著增加（p<0.01）。对对照兔子给予牛磺酸和GES 8周，对血流动力学和心脏牛磺酸含量均无影响。得出的结论是，牛磺酸减缓了心力衰竭的快速进展，从而延长了预期寿命。