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结直肠癌中氨基酸代谢的特征

Characteristics of amino acid metabolism in colorectal cancer.

作者信息

Xu Fen, Jiang Hong-Liang, Feng Wei-Wei, Fu Chen, Zhou Jiang-Chang

机构信息

Department of Gastroenterology, Xinhua Hospital Affiliated to Dalian University, Dalian 116000, Liaoning Province, China.

出版信息

World J Clin Cases. 2023 Sep 26;11(27):6318-6326. doi: 10.12998/wjcc.v11.i27.6318.

Abstract

In recent years, metabolomics research has become a hot spot in the screening and treatment of cancer. It is a popular technique for the quantitative characterization of small molecular compounds in biological cells, tissues, organs or organisms. Further study of the tumor revealed that amino acid changes may occur early in the tumor. The rapid growth and metabolism required for survival result in tumors exhibiting an increased demand for amino acids. An abundant supply of amino acids is important for cancer to maintain its proliferative driving force. Changes in amino acid metabolism can be used to screen malignant tumors and improve therapeutic outcomes. Therefore, it is particularly important to study the characteristics of amino acid metabolism in colorectal cancer. This article reviews several specific amino acid metabolism characteristics in colorectal cancer.

摘要

近年来,代谢组学研究已成为癌症筛查和治疗的热点。它是一种用于定量表征生物细胞、组织、器官或生物体中小分子化合物的常用技术。对肿瘤的进一步研究表明,肿瘤早期可能会发生氨基酸变化。肿瘤生存所需的快速生长和代谢导致其对氨基酸的需求增加。充足的氨基酸供应对癌症维持其增殖驱动力很重要。氨基酸代谢的变化可用于筛查恶性肿瘤并改善治疗效果。因此,研究结直肠癌中氨基酸代谢的特征尤为重要。本文综述了结直肠癌中几种特定的氨基酸代谢特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfb4/10601002/31b90aaf2f1b/WJCC-11-6318-g001.jpg

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