从多孔菌 MUCL 56355 的培养物中分离得到的诱导神经突生长的角鲨烷型倍半萜。
Neurite Outgrowth-Inducing Drimane-Type Sesquiterpenoids Isolated from Cultures of the Polypore MUCL 56355.
机构信息
Department of Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.
Institute of Microbiology, Technische Universität Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany.
出版信息
J Nat Prod. 2023 Nov 24;86(11):2457-2467. doi: 10.1021/acs.jnatprod.3c00525. Epub 2023 Nov 1.
Abundisporin A (), together with seven previously undescribed drimane sesquiterpenes named abundisporins B-H (-), were isolated from a polypore, MUCL 56355 (Polyporaceae), collected in Kenya. Chemical structures of the isolated compounds were elucidated based on exhaustive 1D and 2D NMR spectroscopic measurements and supported by HRESIMS data. The absolute configurations of the isolated compounds were determined by using Mosher's method for - and TDDFT-ECD calculations for and -. None of the isolated compounds exhibited significant activities in either antimicrobial or cytotoxicity assays. Notably, all of the tested compounds demonstrated neurotrophic effects, with and significantly increasing outgrowth of neurites when treated with 5 ng/mL NGF.
Abundisporin A（）与另外七种以前未描述的倍半萜 drimane 化合物 abundisporins B-H（-）一起，从肯尼亚采集的一种多孔菌（Polyporaceae）MUCL 56355 中分离得到。基于全面的 1D 和 2D NMR 波谱测量和 HRESIMS 数据，确定了分离化合物的化学结构。使用 Mosher 方法和 TDDFT-ECD 计算确定了分离化合物的绝对构型和。在所测试的化合物中，没有一种表现出显著的抗菌或细胞毒性活性。值得注意的是，所有测试的化合物均显示出神经营养作用，当用 5ng/mL NGF 处理时，和显著增加了神经突的生长。
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