二氯乙酸在体内的肾脏效应。

Renal effects of dichloroacetate in vivo.

作者信息

Kodama H, Yamaguchi S, Okabe I, Kodama M, Orii T, Kamoshita S

出版信息

Clin Chim Acta. 1986 Nov 15;160(3):265-71. doi: 10.1016/0009-8981(86)90193-2.

Abstract

We have investigated the effect of dichloroacetate (DCA) on the urinary excretion of lactate and pyruvate in a patient with congenital lactic acidosis and in healthy human controls. DCA administered orally in doses of 50 mg/kg and 30 mg/kg decreased plasma lactate and pyruvate of both the patient and the controls, while the urinary excretion of lactate and pyruvate was increased. However, these urinary increments were too small to contribute to the decrease of plasma lactate and pyruvate.

摘要

我们研究了二氯乙酸（DCA）对一名先天性乳酸性酸中毒患者及健康人体对照者尿液中乳酸和丙酮酸排泄的影响。以50mg/kg和30mg/kg的剂量口服DCA后，患者和对照者的血浆乳酸和丙酮酸水平均降低，而尿液中乳酸和丙酮酸的排泄量增加。然而，这些尿液中排泄量的增加过小，不足以导致血浆乳酸和丙酮酸水平的降低。