Local anaesthetics. IV--Synthesis and activity of 2-(N-substituted or N,N-disubstituted aminoacetamido)-4- or -4,5-substituted thiazoles.

Synthesis is described of eleven new 2-(N-substituted or N,N-disubstituted aminoacetamido)-4- or -4,5-substituted thiazoles (I). Their hydrochlorides were screened for local anaesthetic activity on frogs by the sciatic plexus method and the activity compared with that of procaine.