Alkan Cigdem, Jurado-Cobena Eduardo, Ikegami Tetsuro
Department of Pathology, The University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX, 77555, USA.
Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, 301 University Blvd, Galveston, TX, 77555, USA.
NPJ Vaccines. 2023 Nov 4;8(1):171. doi: 10.1038/s41541-023-00769-w.
Rift Valley fever (RVF) is a zoonotic viral disease transmitted by mosquitoes and causes abortion storms, fetal malformations, and newborn animal deaths in livestock ruminants. In humans, RVF can manifest as hemorrhagic fever, encephalitis, or retinitis. Outbreaks of RVF have been occurring in Africa since the early 20th century and continue to pose a threat to both humans and animals in various regions such as Africa, Madagascar, the Comoros, Saudi Arabia, and Yemen. The development of RVF vaccines is crucial in preventing mortality and morbidity and reducing the spread of the virus. While several veterinary vaccines have been licensed in endemic countries, there are currently no licensed RVF vaccines for human use. This review provides an overview of the existing RVF vaccines, as well as potential candidates for future studies on RVF vaccine development, including next-generation vaccines that show promise in combating the disease in both humans and animals.
裂谷热（RVF）是一种由蚊子传播的人畜共患病毒性疾病，可导致家畜反刍动物出现流产风暴、胎儿畸形和新生动物死亡。在人类中，裂谷热可表现为出血热、脑炎或视网膜炎。自20世纪初以来，非洲一直在发生裂谷热疫情，并且继续对非洲、马达加斯加、科摩罗、沙特阿拉伯和也门等各个地区的人类和动物构成威胁。裂谷热疫苗的研发对于预防死亡和发病以及减少病毒传播至关重要。虽然一些兽用疫苗已在流行国家获得许可，但目前尚无用于人类的许可裂谷热疫苗。本综述概述了现有的裂谷热疫苗，以及未来裂谷热疫苗研发研究的潜在候选疫苗，包括在对抗人类和动物疾病方面显示出前景的下一代疫苗。
