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[儿童和青少年甲状腺癌:约22例]

[The thyroid cancer in children and adolescents: about 22 cases].

作者信息

Anajar Said, Tatari Mohammed Moutaa, Lakhbal Adil, Abada Redallah, Rouadi Sami, Roubal Mohammed, Mahtar Mohammed

机构信息

Service Otho-Rhino-Laryngologie et Chirurgie Cervico-faciale, Hôpital 20 Août, Casablanca, Maroc.

出版信息

Pan Afr Med J. 2023 Sep 7;46:9. doi: 10.11604/pamj.2023.46.9.11733. eCollection 2023.

Abstract

Our study of the most representative case series of children and teenagers with thyroid cancer in Morocco (22 cases) aimed to highlight the characteristics of this cancer among children and teenagers and to compare results with those in the international literature. We conducted a retrospective, descriptive study of patients with differentiated thyroid cancer, hospitalized in the Department of Otolaryngology-Head and Neck Surgery at the Hospital in Casablanca, Morocco, over the period January 1995-March 2015. We collected data about 22 cases that met our inclusion criteria. The average age of our patients was 14 years, sex-ratio was 3.4, most of our patients presented with thyroid nodule associated, in 22.7% of cases, with cervical lymphadenopathy and in 9.1% of cases with signs of compression. All patients underwent total thyroidectomy followed by lymph node dissection in 31.82% of cases. The diagnosis of thyroid cancer was based on anatomo-pathological examination of the surgical specimen which confirmed the diagnosis of papillary carcinoma in 95.4% of cases and of vesicular carcinoma in 4.5% of cases. 100% of cases received I-131 RAI treatment followed by thyroid hormone replacement therapy. Close supervision and regular monitoring enabled the detection of nodal metastasis in 3 patients and of distance metastases in 4 patients. Differentiated thyroid cancer among children and teenagers is rare but aggressive, its treatment is based on surgery associated with iratherapy enabling excellent prognosis.

摘要

我们对摩洛哥最具代表性的儿童和青少年甲状腺癌病例系列(22例)进行了研究,旨在突出这种癌症在儿童和青少年中的特征,并将结果与国际文献中的结果进行比较。我们对1995年1月至2015年3月期间在摩洛哥卡萨布兰卡医院耳鼻咽喉-头颈外科住院的分化型甲状腺癌患者进行了一项回顾性描述性研究。我们收集了符合纳入标准的22例病例的数据。我们患者的平均年龄为14岁,性别比为3.4,大多数患者表现为甲状腺结节,22.7%的病例伴有颈部淋巴结病,9.1%的病例有压迫体征。所有患者均接受了全甲状腺切除术,31.82%的病例随后进行了淋巴结清扫。甲状腺癌的诊断基于手术标本的解剖病理学检查,95.4%的病例确诊为乳头状癌,4.5%的病例为滤泡状癌。100%的病例接受了I-131放射性碘治疗,随后进行甲状腺激素替代治疗。密切监测使得3例患者检测到淋巴结转移,4例患者检测到远处转移。儿童和青少年分化型甲状腺癌虽罕见但具有侵袭性,其治疗基于手术联合放射性碘治疗,预后良好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97dd/10620443/7c2dcfb8eaa5/PAMJ-46-9-g001.jpg

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