白细胞介素-22 与急性胰腺炎：综述。
Interleukin-22 and acute pancreatitis: A review.
机构信息
Department of Gastroenterology, Shandong Provincial Hospital, Shandong University, Jinan, China.
Gastroenterology center, Qingdao Hiser Hospital Affiliated to Qingdao University (Qingdao Traditional Chinese Medicine Hospital), Qingdao, China.
出版信息
Medicine (Baltimore). 2023 Nov 3;102(44):e35695. doi: 10.1097/MD.0000000000035695.
Acute pancreatitis (AP) is one of the most common gastrointestinal diseases, and it is divided into 3 types according to its severity:mild acute pancreatitis, moderately severe acute pancreatitis, and severe acute pancreatitis. The mortality in severe acute pancreatitis is approximately 15% to 30% due to multiorgan dysfunction and the lack of specific treatment. Interleukin-22 (IL-22) is a member of the Interleukin-10 family, and it can activate several downstream signaling pathways by binding to its receptor complex, thus it is involved in cell differentiation, proliferation, and apoptosis. Some studies have reported the elevated level of IL-22 in patients with AP, which suggests IL-22 may be involved in the pathogenesis of AP. And many studies have shown that IL-22 had a protective effect against AP. This article reviews the characteristics and mechanism of IL-22 and its role in AP to provide insight into the treatment of AP.
急性胰腺炎（AP）是最常见的胃肠道疾病之一，根据其严重程度可分为 3 种类型：轻度急性胰腺炎、中度重症急性胰腺炎和重症急性胰腺炎。由于多器官功能障碍和缺乏特异性治疗，重症急性胰腺炎的死亡率约为 15%至 30%。白细胞介素-22（IL-22）是白细胞介素-10 家族的一员，它可以通过与受体复合物结合激活几个下游信号通路，从而参与细胞分化、增殖和凋亡。一些研究报道了 AP 患者中 IL-22 水平升高，这表明 IL-22 可能参与了 AP 的发病机制。许多研究表明，IL-22 对 AP 具有保护作用。本文综述了 IL-22 的特征和机制及其在 AP 中的作用，为 AP 的治疗提供了新的思路。
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