补充α-硫辛酸（ALA）对成年人血压的影响：一项采用GRADE评估的随机对照试验系统评价和剂量反应荟萃分析。
The effects of alpha lipoic acid (ALA) supplementation on blood pressure in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
作者信息
Vajdi Mahdi, Noshadi Nooshin, Hassanizadeh Shirin, Bonyadian Atefeh, Seyedhosseini-Ghaheh Hooria, Askari Gholamreza
机构信息
Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Clinical Nutrition, School of Nutrition and Food Sciences, Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Front Cardiovasc Med. 2023 Oct 24;10:1272837. doi: 10.3389/fcvm.2023.1272837. eCollection 2023.
INTRODUCTION
There have been various clinical studies on the effect of Alpha lipoic acid (ALA) supplementation on blood pressure (BP), but the findings from these are contradictory. Therefore, we performed a systematic review and dose-response meta-analysis to summarize the relation of ALA supplementation and systolic blood pressure (SBP) and diastolic blood pressure (DBP) in adults.
METHODS
A comprehensive search was conducted in Medline (PubMed), Embase, Scopus, and ProQuest up to July 2023. Randomized controlled trials (RCTs) evaluating the effect of ALA on SBP and DBP were included. The pooled weighted mean difference (WMD) of included trials was estimated using a random-effects model. The dose-dependent effect was also assessed.
RESULTS AND DISCUSSION
A total of 11 RCTs with the participation of 674 patients were included. The result of the meta-analysis indicated that using ALA supplementation significantly reduced the SBP (WMD = -5.46 mmHg; 95% CI: -9.27, -1.65; < 0.001) and DBP (WMD = -3.36 mmHg, 95% CI: -4.99, -1.74; < 0.001). The ALA administrations significantly reduced SBP and DBP at the dosages of <800 mg/day, when administered for ≤12 weeks. The present meta-analysis revealed that ALA supplementation could exert favorable effects on SBP and DBP. Further well-designed studies with larger samples are needed to ascertain the long-term effects of ALA on BP.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=447658, identifier PROSPERO: CRD42023447658.
引言
关于补充α硫辛酸（ALA）对血压（BP）的影响已有多项临床研究，但这些研究结果相互矛盾。因此，我们进行了一项系统评价和剂量反应荟萃分析，以总结补充ALA与成年人收缩压（SBP）和舒张压（DBP）之间的关系。
方法
截至2023年7月，在Medline（PubMed）、Embase、Scopus和ProQuest中进行了全面检索。纳入评估ALA对SBP和DBP影响的随机对照试验（RCT）。使用随机效应模型估计纳入试验的合并加权平均差（WMD）。还评估了剂量依赖性效应。
结果与讨论
共纳入11项RCT，674例患者参与。荟萃分析结果表明，补充ALA可显著降低SBP（WMD = -5.46 mmHg；95%CI：-9.27，-1.65；P < 0.001）和DBP（WMD = -3.36 mmHg，95%CI：-4.99，-1.74；P < 0.001）。当ALA剂量<800 mg/天且给药≤12周时，可显著降低SBP和DBP。本荟萃分析表明，补充ALA对SBP和DBP有有益作用。需要进一步开展设计良好的大样本研究，以确定ALA对血压的长期影响。
系统评价注册
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=447658，标识符PROSPERO：CRD42023447658。
Zotero 插件