School of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China.
School of International Education, Henan University of Technology, Zhengzhou 450001, China.
Int J Biol Macromol. 2024 Jan;254(Pt 2):127955. doi: 10.1016/j.ijbiomac.2023.127955. Epub 2023 Nov 7.
Polysaccharides have been widely used in pharmaceutical and food industries due to their diverse bioactivity, high safety, and few or no side effects. However, inability to quickly produce, screen, and synthesize bioactive polysaccharides is the limiting factor for their development and application. Structural features determine and influence the bioactivity of polysaccharides. Among them, monosaccharide is the basic unit of polysaccharide, which not only affects electrification, functional group, and bioactivity of polysaccharide but also is one of the simplest polysaccharide indexes to be detected. At present, effects of monosaccharide composition and proportion on anti-inflammatory, antioxidant, antitumor, immunomodulatory, antibacterial, and prebiotic activities of polysaccharides are reviewed. Further problems need to be considered during regulation and analysis of monosaccharide composition and proportion of polysaccharides. Overall, present work will provide help and reference for production, development, and structure-function investigation of polysaccharides based on their monosaccharide.
多糖由于其多样的生物活性、高安全性以及很少或没有副作用，已被广泛应用于医药和食品工业。然而，由于不能快速生产、筛选和合成具有生物活性的多糖，这成为了它们发展和应用的限制因素。结构特征决定并影响多糖的生物活性。其中，单糖是多糖的基本单元，它不仅影响多糖的电荷、官能团和生物活性，而且是最容易检测的多糖指标之一。目前，综述了单糖组成和比例对多糖的抗炎、抗氧化、抗肿瘤、免疫调节、抗菌和益生元活性的影响。在调节和分析多糖的单糖组成和比例时，还需要进一步考虑其他问题。总的来说，这项工作将为基于单糖的多糖的生产、开发和结构-功能研究提供帮助和参考。
