School of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, PR China; Department of Soft Matter, Institute of Physics, Otto-von-Guericke University, Magdeburg 39106, Germany; Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China.
School of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, PR China.
Ultrason Sonochem. 2023 Dec;101:106690. doi: 10.1016/j.ultsonch.2023.106690. Epub 2023 Nov 7.
As a safe and effective method for systemic transdermal drug delivery (TDD), sonophoresis has drawn much attention from researchers. Despite numerous studies confirming cavitation as the main reason for sonophoresis, the effect skin has on cavitation bubble dynamics remains elusive due to the difficulty of experimental challenges. For a start, we reveal how single cavitation bubble (SCB) dynamics are affected by skin properties, including elasticity, hydrophilicity and texture. We use polydimethylsiloxane (PDMS) to simulate human skin and record the temporary evolution of SCBs with synchronous ultrafast photography. The influences of skin properties on SCBs are concluded: 1) SCBs collapse later near walls with better elasticities and generate microjets with higher speed; 2) SCBs collapse later near hydrophilic walls with slower microjets; and 3) the existence of a texture structure on walls also delays the time of bubble collapse near them and slows the velocities of microjets (v) during collapses.
声透法作为一种安全有效的全身经皮药物输送（TDD）方法，引起了研究人员的广泛关注。尽管有大量研究证实空化是声透法的主要原因，但由于实验挑战的困难，皮肤对空化气泡动力学的影响仍然难以捉摸。首先，我们揭示了皮肤特性（包括弹性、亲水性和质地）如何影响单个空化气泡（SCB）的动力学。我们使用聚二甲基硅氧烷（PDMS）模拟人体皮肤，并使用同步超快摄影记录 SCB 的临时演变。皮肤特性对 SCB 的影响总结如下：1）在弹性更好的壁附近，SCB 更晚坍塌，并产生速度更高的微射流；2）在亲水壁附近，SCB 更晚坍塌，微射流速度更慢；3）壁上存在纹理结构也会延迟附近气泡的坍塌时间，并在坍塌过程中降低微射流（v）的速度。
