金黄色葡萄球菌菌血症的当代管理-临床实践中的争议。
Contemporary Management of Staphylococcus aureus Bacteremia-Controversies in Clinical Practice.
机构信息
Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Division of HIV, Infectious Diseases, and Global Medicine at Zuckerberg San Francisco General Hospital, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
出版信息
Clin Infect Dis. 2023 Nov 30;77(11):e57-e68. doi: 10.1093/cid/ciad500.
Abstract
Staphylococcus aureus bacteremia (SAB) carries a high risk for excess morbidity and mortality. Despite its prevalence, significant practice variation continues to permeate clinical management of this syndrome. Since the publication of the 2011 Infectious Diseases Society of America (IDSA) guidelines on management of methicillin-resistant Staphylococcus aureus infections, the field of SAB has evolved with the emergence of newer diagnostic strategies and therapeutic options. In this review, we seek to provide a comprehensive overview of the evaluation and management of SAB, with special focus on areas where the highest level of evidence is lacking to inform best practices.
摘要
金黄色葡萄球菌菌血症 (SAB) 会导致过高的发病率和死亡率。尽管它很常见，但在这种综合征的临床管理中，仍存在着显著的实践差异。自 2011 年美国传染病学会 (IDSA) 关于耐甲氧西林金黄色葡萄球菌感染管理的指南发布以来，随着新的诊断策略和治疗选择的出现，SAB 领域已经发展。在这篇综述中，我们旨在全面概述 SAB 的评估和管理，特别关注缺乏最高水平证据的领域，以提供最佳实践的信息。
相似文献
1
Contemporary Management of Staphylococcus aureus Bacteremia-Controversies in Clinical Practice.金黄色葡萄球菌菌血症的当代管理-临床实践中的争议。
Clin Infect Dis. 2023 Nov 30;77(11):e57-e68. doi: 10.1093/cid/ciad500.
2
The Utility of Risk Factors to Define Complicated Staphylococcus aureus Bacteremia in a Setting With Low Methicillin-Resistant S. aureus Prevalence.低耐甲氧西林金黄色葡萄球菌流行环境下，危险因素对于明确金黄色葡萄球菌菌血症并发症的作用。
Clin Infect Dis. 2024 Apr 10;78(4):846-854. doi: 10.1093/cid/ciad784.
3
[Methicillin-susceptible Staphylococcus aureus bacteraemia].[甲氧西林敏感金黄色葡萄球菌菌血症]
Rev Med Suisse. 2022 Oct 12;18(799):1889-1895. doi: 10.53738/REVMED.2022.18.799.1889.
4
Clinical Management of Bacteremia in Neonates, Children, and Adolescents.儿童和青少年菌血症的临床管理
Pediatrics. 2020 Sep;146(3). doi: 10.1542/peds.2020-0134. Epub 2020 Aug 5.
5
Executive Summary: State-of-The-Art Review: Contemporary Management of Staphylococcus aureus Bacteremia: Controversies in Clinical Practice.执行摘要：最新综述：金黄色葡萄球菌菌血症的当代管理：临床实践中的争议
Clin Infect Dis. 2023 Nov 30;77(11):1489-1491. doi: 10.1093/cid/ciad525.
6
Global Differences in the Management of Staphylococcus aureus Bacteremia: No International Standard of Care.全球金黄色葡萄球菌菌血症管理的差异：没有国际标准的治疗方法。
Clin Infect Dis. 2023 Oct 13;77(8):1092-1101. doi: 10.1093/cid/ciad363.
7
Clinical Practice Variation Among Adult Infectious Disease Physicians in the Management of Staphylococcus aureus Bacteremia.成人感染病医师在金黄色葡萄球菌菌血症管理方面的临床实践差异。
Clin Infect Dis. 2019 Jul 18;69(3):530-533. doi: 10.1093/cid/ciy1144.
8
Management and outcomes in patients with Staphylococcus aureus bacteremia after implementation of mandatory infectious diseases consult: a before/after study.实施强制性传染病会诊后金黄色葡萄球菌菌血症患者的管理与结局：一项前后对照研究
BMC Infect Dis. 2015 Dec 15;15:568. doi: 10.1186/s12879-015-1296-y.
9
Pharmacotherapeutic options for treating Staphylococcus aureus bacteremia.治疗金黄色葡萄球菌菌血症的药物治疗选择。
Expert Opin Pharmacother. 2017 Dec;18(18):1947-1963. doi: 10.1080/14656566.2017.1403585. Epub 2017 Dec 4.
10
Complete adherence to evidence-based quality-of-care indicators for Staphylococcus aureus bacteremia resulted in better prognosis.完全遵循金黄色葡萄球菌菌血症的循证医疗质量指标可带来更好的预后。
Infection. 2017 Feb;45(1):83-91. doi: 10.1007/s15010-016-0946-3. Epub 2016 Oct 5.
引用本文的文献
1
Evaluating chain-of-thought prompting in a GPT chatbot for BCID2 interpretation and stewardship: how does AI compare to human experts?评估用于BCID2解读与管理的GPT聊天机器人中的思维链提示：人工智能与人类专家相比如何？
Antimicrob Steward Healthc Epidemiol. 2025 Jul 11;5(1):e154. doi: 10.1017/ash.2025.10059. eCollection 2025.
2
The role of [18F]FDG-PET/CT in Staphylococcus aureus bacteremia: A clinical perspective.[18F]氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（[18F]FDG-PET/CT）在金黄色葡萄球菌菌血症中的作用：临床视角
Npj Imaging. 2024 Sep 13;2(1):32. doi: 10.1038/s44303-024-00036-0.
3
Combination therapy with fosfomycin for bacteraemia or endocarditis: a systematic review and meta-analysis of randomized trials.磷霉素联合治疗菌血症或心内膜炎：随机试验的系统评价和荟萃分析
JAC Antimicrob Resist. 2025 Jun 17;7(3):dlaf101. doi: 10.1093/jacamr/dlaf101. eCollection 2025 Jun.
4
Impact of Substance Use Disorders on Outcomes of Medically Insured Persons Receiving Multiweek Outpatient Parenteral Antimicrobial Therapy: a Claims-based Cohort Study From 2015 to 2020.物质使用障碍对接受多周门诊胃肠外抗菌治疗的参保人员治疗结果的影响：一项基于2015年至2020年索赔数据的队列研究
Open Forum Infect Dis. 2025 Jun 2;12(6):ofaf315. doi: 10.1093/ofid/ofaf315. eCollection 2025 Jun.
5
A multi-hospital, clinician-initiated bacterial genomics programme to investigate treatment failure in severe Staphylococcus aureus infections.一项由临床医生发起的多医院细菌基因组学项目，旨在调查严重金黄色葡萄球菌感染的治疗失败情况。
Nat Commun. 2025 May 26;16(1):4869. doi: 10.1038/s41467-025-60045-4.
6
Antibiotic adherence and treatment completion associated with partial oral therapy versus all intravenous therapy in patients with serious Staphylococcus aureus infections.严重金黄色葡萄球菌感染患者中，部分口服治疗与全静脉治疗的抗生素依从性及治疗完成情况对比
BMC Infect Dis. 2025 May 17;25(1):714. doi: 10.1186/s12879-025-11098-9.
7
Genomic investigation of MRSA bacteremia relapse reveals diverse genomic profiles but convergence in bacteremia-associated genes.耐甲氧西林金黄色葡萄球菌菌血症复发的基因组研究揭示了不同的基因组图谱，但在菌血症相关基因方面存在趋同现象。
medRxiv. 2025 Mar 28:2025.03.24.25324140. doi: 10.1101/2025.03.24.25324140.
8
Impact of adherence to quality indicators and effects of targeted treatment with cefazolin or flucloxacillin on in-hospital mortality in patients with methicillin-susceptible Staphylococcus aureus (MSSA) bloodstream infections: a retrospective observational study.遵循质量指标的影响以及头孢唑林或氟氯西林靶向治疗对甲氧西林敏感金黄色葡萄球菌（MSSA）血流感染患者院内死亡率的影响：一项回顾性观察研究。
Infection. 2025 Jan 27. doi: 10.1007/s15010-025-02473-4.
9
Data Mining Models in Prediction of Vancomycin-Intermediate in Methicillin-Resistant (MRSA) Bacteremia Patients in a Clinical Care Setting.临床护理环境中耐甲氧西林金黄色葡萄球菌（MRSA）菌血症患者万古霉素中介预测中的数据挖掘模型
Microorganisms. 2025 Jan 7;13(1):101. doi: 10.3390/microorganisms13010101.
10
Diagnostic methods and protocols for rapid determination of methicillin resistance in Staphylococcus aureus bloodstream infections: a comparative analysis.金黄色葡萄球菌血流感染中耐甲氧西林快速检测的诊断方法与方案：一项比较分析
Eur J Clin Microbiol Infect Dis. 2025 Apr;44(4):827-837. doi: 10.1007/s10096-025-05039-2. Epub 2025 Jan 22.
本文引用的文献
1
Ceftobiprole for Treatment of Complicated Bacteremia.头孢托罗匹酯治疗复杂菌血症。
N Engl J Med. 2023 Oct 12;389(15):1390-1401. doi: 10.1056/NEJMoa2300220. Epub 2023 Sep 27.
2
Treatment decisions in VRE bacteraemia: a survey of infectious diseases pharmacists.耐万古霉素肠球菌菌血症的治疗决策：对传染病药剂师的一项调查
JAC Antimicrob Resist. 2023 May 22;5(3):dlad063. doi: 10.1093/jacamr/dlad063. eCollection 2023 Jun.
3
Safe shortening of antibiotic treatment duration for complicated bacteraemia (SAFE trial): protocol for a randomised, controlled, open-label, non-inferiority trial comparing 4 and 6 weeks of antibiotic treatment.安全缩短复杂菌血症的抗生素治疗疗程（SAFE 试验）：比较 4 周和 6 周抗生素治疗的随机、对照、开放标签、非劣效性试验方案。
BMJ Open. 2023 Apr 21;13(4):e068295. doi: 10.1136/bmjopen-2022-068295.
4
Real-World Application of Oral Therapy for Infective Endocarditis: A Multicenter, Retrospective, Cohort Study.真实世界中感染性心内膜炎的口服治疗应用：一项多中心回顾性队列研究。
Clin Infect Dis. 2023 Sep 11;77(5):672-679. doi: 10.1093/cid/ciad119.
5
Positive Impact of [18F]FDG-PET/CT on Mortality in Patients With Staphylococcus aureus Bacteremia Explained by Immortal Time Bias.18F]FDG-PET/CT 对金黄色葡萄球菌菌血症患者死亡率的积极影响可归因于无失访时间偏倚。
Clin Infect Dis. 2023 Jul 5;77(1):9-15. doi: 10.1093/cid/ciad112.
6
Sequential oral antibiotic in uncomplicated Staphylococcus aureus bacteraemia: a propensity-matched cohort analysis.序贯口服抗生素治疗单纯金黄色葡萄球菌菌血症：一项倾向评分匹配队列分析。
Clin Microbiol Infect. 2023 Jun;29(6):744-750. doi: 10.1016/j.cmi.2023.02.001. Epub 2023 Feb 10.
7
Successful use of nafcillin and ceftaroline combination therapy for persistent MSSA bacteraemia and endocarditis: a case series.萘夫西林和头孢洛林联合治疗持续性甲氧西林敏感金黄色葡萄球菌菌血症和心内膜炎的成功应用：病例系列
JAC Antimicrob Resist. 2022 Dec 29;5(1):dlac129. doi: 10.1093/jacamr/dlac129. eCollection 2023 Feb.
8
Cefazolin in the treatment of central nervous system infections: A narrative review and recommendation.头孢唑林治疗中枢神经系统感染：一项叙述性综述与建议
Pharmacotherapy. 2023 Jan;43(1):85-95. doi: 10.1002/phar.2750. Epub 2023 Jan 22.
9
Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019.2019 年与 33 种细菌病原体相关的全球死亡率：2019 年全球疾病负担研究的系统分析。
Lancet. 2022 Dec 17;400(10369):2221-2248. doi: 10.1016/S0140-6736(22)02185-7. Epub 2022 Nov 21.
10
Deconstructing the Dogma: Systematic Literature Review and Meta-analysis of Adjunctive Gentamicin and Rifampin in Staphylococcal Prosthetic Valve Endocarditis.解构教条：葡萄球菌人工瓣膜心内膜炎中庆大霉素和利福平辅助治疗的系统文献综述与荟萃分析
Open Forum Infect Dis. 2022 Oct 31;9(11):ofac583. doi: 10.1093/ofid/ofac583. eCollection 2022 Nov.
Zotero 插件