节枝菌素 A-D，四种新的倍半萜类化合物，来自红树林沉积物来源真菌 sp. SCSIO41221。

Arthproliferins A-D, Four New Sesterterpenes from the Mangrove-Sediment-Derived Fungus sp. SCSIO41221.

机构信息

CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.

Marine Environmental Engineering Center, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510515, China.

出版信息

Molecules. 2023 Oct 24;28(21):7246. doi: 10.3390/molecules28217246.

DOI:10.3390/molecules28217246

PMID:37959666

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10648114/

Abstract

Four new sesterterpenes, arthproliferins A-D (-), together with four known derivatives, were isolated and characterized from the mangrove-sediment-derived fungus sp. SCSIO41221. Their structures were determined using detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses. Some of the isolated compounds were evaluated for their cytotoxicity in vitro. The results revealed that terpestacin () exhibited significant activity with an IC value of 20.3 μM, and compounds and were found to show weak inhibitory effects against U87MG-derived GSCs.

摘要

从红树林沉积物来源的真菌 sp. SCSIO41221 中分离并鉴定了四个新的倍半萜类化合物，arthproliferins A-D(-)，以及四个已知衍生物。通过详细的核磁共振（NMR）和质谱（MS）分析确定了它们的结构。对一些分离得到的化合物进行了体外细胞毒性评价。结果表明，terpestacin()具有显著的活性，IC 值为 20.3 μM，化合物和显示出对 U87MG 来源的 GSCs 的弱抑制作用。