Department of Cardiology, Wuxi Clinical College of Anhui Medical University, Wuxi, Jiangsu, 214044, People's Republic of China.
Department of Cardiology, The 904Th Hospital of the PLA Joint Logistics Support Force, Wuxi, 214044, Jiangsu, People's Republic of China.
J Cardiovasc Transl Res. 2024 Jun;17(3):657-668. doi: 10.1007/s12265-023-10457-8. Epub 2023 Nov 14.
We aimed to evaluate the correlation among serum parathyroid hormone (PTH) and slow-reflow during primary percutaneous coronary intervention (PCI) and prognosis in patients with ST-segment elevation myocardial infarction (STEMI). A total of 262 patients were enrolled and divided into a slow-reflow group (n = 61) and a control group (n = 201). PTH was an independent risk factor for slow-reflow (P < 0.05), and the regression model had good discrimination and calibration. ROC curve analysis showed that PTH (≥ 63.65 pg/ml) had a predictive value for slow-reflow (P < 0.001). During the 1-year follow-up, the patients were divided into a PTH-h group (≥ 63.65 pg/ml, n = 100) and a PTH-l group (< 63.65 pg/ml, n = 162). Readmission for HF was independently associated with PTH levels (P < 0.05). KM survival analysis suggested that PTH-h had a predictive value for MACEs, especially for readmission for HF (P < 0.05). PTH levels were associated with slow-reflow during PCI and MACEs during follow-up in patients with STEMI.
我们旨在评估原发性经皮冠状动脉介入治疗（PCI）期间血清甲状旁腺激素（PTH）与慢血流之间的相关性及其对 ST 段抬高型心肌梗死（STEMI）患者预后的影响。共纳入 262 例患者，分为慢血流组（n=61）和对照组（n=201）。PTH 是慢血流的独立危险因素（P<0.05），回归模型具有良好的判别和校准能力。ROC 曲线分析显示，PTH（≥63.65 pg/ml）对慢血流具有预测价值（P<0.001）。在 1 年的随访中，患者分为 PTH-h 组（≥63.65 pg/ml，n=100）和 PTH-l 组（<63.65 pg/ml，n=162）。HF 再入院与 PTH 水平独立相关（P<0.05）。KM 生存分析表明，PTH-h 对 MACEs 有预测价值，尤其是 HF 再入院（P<0.05）。PTH 水平与 STEMI 患者 PCI 期间的慢血流和随访期间的 MACEs 相关。
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