Huang Chunjie, Esfani Sarafraz Pooya, Enayati Parisa, Mortazavi Mamaghani Elham, Babakhanzadeh Emad, Nazari Majid
School of Medicine, Nantong University, Nantong, China.
Department of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran.
Cancer Cell Int. 2023 Nov 22;23(1):288. doi: 10.1186/s12935-023-03128-w.
CircRNAs, a special type of noncoding RNAs characterized by their stable structure and unique abilities to form backsplicing loops, have recently attracted the interest of scientists. These RNAs are abundant throughout the body and play important roles such as microRNA sponges, templates for transcription, and regulation of protein translation and RNA-binding proteins. Renal cancer development is highly correlated with abnormal circRNA expression in vivo. CircRNAs are currently considered promising targets for novel therapeutic approaches as well as possible biomarkers for prognosis and diagnosis of various malignancies. Despite our growing understanding of circRNA, numerous questions remain unanswered. Here, we address the characteristics of circRNAs and their function, focusing in particular on their impact on drug resistance, metabolic processes, metastasis, cell growth, and programmed cell death in renal cancer. In addition, the application of circRNAs as prognostic and diagnostic biomarkers will be discussed.
环状RNA（circRNAs）是一种特殊类型的非编码RNA，其特点是结构稳定，具有形成反向剪接环的独特能力，最近引起了科学家们的关注。这些RNA在全身广泛存在，并发挥着重要作用，如作为微小RNA海绵、转录模板以及调节蛋白质翻译和RNA结合蛋白。肾癌的发生与体内环状RNA表达异常高度相关。环状RNA目前被认为是新型治疗方法的有前景的靶点，以及各种恶性肿瘤预后和诊断的潜在生物标志物。尽管我们对环状RNA的了解不断增加，但仍有许多问题未得到解答。在此，我们阐述环状RNA的特征及其功能，特别关注它们对肾癌耐药性、代谢过程、转移、细胞生长和程序性细胞死亡的影响。此外，还将讨论环状RNA作为预后和诊断生物标志物的应用。
