Department of Psychiatry and Clinical Psychology, Hospital Universitari i Politècnic La Fe.
Genetic Counselling Unit for Hereditary Cancer, Department of Oncology, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
Eur J Cancer Prev. 2024 Jul 1;33(4):293-298. doi: 10.1097/CEJ.0000000000000862. Epub 2023 Nov 13.
Few studies have examined the prevalence of cancer worry in the general and at-risk population. The objective of this study was to describe the prevalence of cancer worry in a sample of individuals at increased risk of developing hereditary cancer, determine differences in cancer worry by socio-demographic characteristics and assess the relationship between cancer worry and psychological distress.
A cross-sectional study was designed with 895 patients. The Cancer Worry Scale (CWS), Hospital Anxiety and Depression Scale (HADS) for psychological distress and sociodemographic characteristics were examined. The multiple linear regression model was developed to explore what variables were predicted for cancer worry. To identify variables associated with higher cancer worry scores, a logistic model was fitted.
In the at-higher-risk sample of hereditary cancer, the mean of CWS was 10.20 (SD: 3.70). The significant predictors for cancer worry were gender, age, previous psychiatric treatment, patients affected by cancer and having children. In the sample, 38% of patients had higher scores on cancer worry, the variables associated were patients affected by cancer compared, women, widow/divorced participants, less than secondary school, patients with previous psychiatric treatment and patients less than 55 years old. Using the HADS cutoff score 29% of the sample showed significant psychological distress, more anxiety (35%) than depressive (22%) symptomatology. Psychological distress showed a higher variability (36%) on cancer worry.
Findings highlighted distinctive profiles in socio-demographic characteristics according to the degree of cancer worry; therefore, genetic counseling should continue to be provided to address cancer worry and relieve psychological distress.
很少有研究调查一般人群和高危人群中癌症担忧的流行情况。本研究的目的是描述遗传性癌症高危人群中癌症担忧的流行情况，确定癌症担忧在社会人口统计学特征上的差异，并评估癌症担忧与心理困扰之间的关系。
设计了一项横断面研究，共纳入 895 名患者。使用癌症担忧量表（CWS）、医院焦虑抑郁量表（HADS）评估心理困扰和社会人口统计学特征。采用多元线性回归模型探索哪些变量可预测癌症担忧。为了确定与更高的癌症担忧评分相关的变量，拟合了逻辑回归模型。
在遗传性癌症高危人群样本中，CWS 的平均值为 10.20（标准差：3.70）。癌症担忧的显著预测因素是性别、年龄、既往精神科治疗、癌症患者和有子女。在该样本中，38%的患者癌症担忧评分较高，相关变量为癌症患者、女性、丧偶/离异患者、受教育程度较低、有既往精神科治疗史和年龄小于 55 岁的患者。使用 HADS 截断值 29%的样本显示出显著的心理困扰，焦虑（35%）症状比抑郁（22%）症状更为明显。心理困扰对癌症担忧的变异性更大（36%）。
研究结果根据癌症担忧程度突出了社会人口统计学特征的不同特征；因此，遗传咨询应继续提供，以解决癌症担忧和缓解心理困扰。
