Wu Qiong, Ren Qiuyang, Meng Jingsi, Gao Wei-Juan, Chang Yan-Zhong
Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.
Ministry of Education Key Laboratory of Molecular and Cellular Biology, The Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, No. 20 Nan'erhuan Eastern Road, Shijiazhuang 050024, China.
Antioxidants (Basel). 2023 Nov 13;12(11):1997. doi: 10.3390/antiox12111997.
Iron plays an essential role in various physiological processes. A disruption in iron homeostasis can lead to severe consequences, including impaired neurodevelopment, neurodegenerative disorders, stroke, and cancer. Interestingly, the link between mental health disorders and iron homeostasis has not received significant attention. Therefore, our understanding of iron metabolism in the context of psychological diseases is incomplete. In this review, we aim to discuss the pathologies and potential mechanisms that relate to iron homeostasis in associated mental disorders. We propose the hypothesis that maintaining brain iron homeostasis can support neuronal physiological functions by impacting key enzymatic activities during neurotransmission, redox balance, and myelination. In conclusion, our review highlights the importance of investigating the relationship between trace element nutrition and the pathological process of mental disorders, focusing on iron. This nutritional perspective can offer valuable insights for the clinical treatment of mental disorders.
铁在各种生理过程中起着至关重要的作用。铁稳态的破坏会导致严重后果，包括神经发育受损、神经退行性疾病、中风和癌症。有趣的是，心理健康障碍与铁稳态之间的联系尚未得到足够的关注。因此，我们对心理疾病背景下铁代谢的理解并不完整。在这篇综述中，我们旨在讨论相关精神障碍中与铁稳态有关的病理和潜在机制。我们提出一个假设，即维持大脑铁稳态可以通过影响神经传递、氧化还原平衡和髓鞘形成过程中的关键酶活性来支持神经元的生理功能。总之，我们的综述强调了研究微量元素营养与精神障碍病理过程之间关系的重要性，重点是铁。这种营养观点可以为精神障碍的临床治疗提供有价值的见解。
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