Boicean Adrian, Birlutiu Victoria, Ichim Cristian, Brusnic Olga, Onișor Danusia Maria
County Clinical Emergency Hospital of Sibiu, 550245 Sibiu, Romania.
Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.
Biomedicines. 2023 Oct 30;11(11):2930. doi: 10.3390/biomedicines11112930.
The human gastrointestinal tract houses a diverse array of probiotic and pathogenic bacteria and any alterations in this microbial composition can exert a significant influence on an individual's well-being. It is well-established that imbalances in the gut microbiota play a pivotal role in the development of liver diseases. In light of this, a new adjuvant therapy for liver diseases could be regulating the intestinal microbiota. Through fecal microbiota transplantation, patients whose microbiomes are compromised are treated with stool from healthy donors in an attempt to restore a normal microbiome and alleviate their symptoms. A review of cross-sectional studies and case reports suggests that fecal microbiota transplants may offer effective treatment for chronic liver diseases. Adding to the potential of this emerging therapy, recent research has indicated that fecal microbiota transplantation holds promise as a therapeutic approach specifically for liver cirrhosis. By introducing a diverse range of beneficial microorganisms into the gut, this innovative treatment aims to address the microbial imbalances often observed in cirrhotic patients. While further validation is still required, these preliminary findings highlight the potential impact of fecal microbiota transplantation as a novel and targeted method for managing liver cirrhosis. We aimed to summarize the current state of understanding regarding this procedure, as a new therapeutic method for liver cirrhosis, as well as to explain its clinical application and future potential.
人类胃肠道中栖息着各种各样的益生菌和致病菌,这种微生物组成的任何改变都可能对个体的健康产生重大影响。众所周知,肠道微生物群的失衡在肝脏疾病的发展中起着关键作用。有鉴于此,一种新的肝脏疾病辅助治疗方法可能是调节肠道微生物群。通过粪便微生物群移植,微生物群受损的患者接受来自健康供体的粪便治疗,试图恢复正常的微生物群并缓解他们的症状。一项对横断面研究和病例报告的综述表明,粪便微生物群移植可能为慢性肝脏疾病提供有效的治疗方法。这一新兴疗法的潜力还不止于此,最近的研究表明,粪便微生物群移植有望成为一种专门治疗肝硬化的方法。通过将多种有益微生物引入肠道,这种创新疗法旨在解决肝硬化患者中经常出现的微生物失衡问题。虽然仍需要进一步验证,但这些初步发现凸显了粪便微生物群移植作为一种治疗肝硬化的新型靶向方法的潜在影响。我们旨在总结关于这一治疗方法作为肝硬化新治疗手段的当前认识状态,并解释其临床应用和未来潜力。