de Carvalho Ana Clara Wada, Paiva Natália Floriano, Demonari Isabella Kriunas, Duarte Maíra Peres Ferreira, do Couto Renê Oliveira, de Freitas Osvaldo, Vicentini Fabiana Testa Moura de Carvalho
School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil. Av. Café, Ribeirão Preto 14048-900, SP, Brazil.
Campus Centro-Oeste Dona Lindu (CCO), Universidade Federal de São João del-Rei (UFSJ), Divinópolis 35501-296, MG, Brazil.
Pharmaceutics. 2023 Nov 4;15(11):2583. doi: 10.3390/pharmaceutics15112583.
Pharmaceutical films are polymeric formulations used as a delivery platform for administration of small and macromolecular drugs for local or systemic action. They can be produced by using synthetic, semi-synthetic, or natural polymers through solvent casting, electrospinning, hot-melt extrusion, and 3D printing methods, and depending on the components and the manufacturing methods used, the films allow the modulation of drug release. Moreover, they have advantages that have drawn interest in the development and evaluation of film application on the buccal, nasal, vaginal, and ocular mucosa. This review aims to provide an overview of and critically discuss the use of films as transmucosal drug delivery systems. For this, aspects such as the composition of these formulations, the theories of mucoadhesion, and the methods of production were deeply considered, and an analysis of the main transmucosal pathways for which there are examples of developed films was conducted. All of this allowed us to point out the most relevant characteristics and opportunities that deserve to be taken into account in the use of films as transmucosal drug delivery systems.
药用薄膜是一种聚合物制剂，用作小分子和大分子药物的给药平台，可产生局部或全身作用。它们可以通过溶剂浇铸、静电纺丝、热熔挤出和3D打印方法，使用合成聚合物、半合成聚合物或天然聚合物来制备。根据所用的成分和制造方法，这些薄膜能够调节药物释放。此外，它们具有的优势引起了人们对在颊黏膜、鼻黏膜、阴道黏膜和眼黏膜上开发和评估薄膜应用的兴趣。本综述旨在概述并批判性地讨论薄膜作为透黏膜给药系统的应用。为此，深入考虑了这些制剂的组成、黏膜黏附理论和生产方法等方面，并对已有薄膜制剂实例的主要透黏膜途径进行了分析。所有这些使我们能够指出在将薄膜用作透黏膜给药系统时值得考虑的最相关特性和机遇。
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