基于活动记录仪的睡眠测量与英国生物库中前列腺癌风险的关系。

Actigraphy-derived measures of sleep and risk of prostate cancer in the UK Biobank.

机构信息

Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Risk Factor Assessment Branch, Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

出版信息

J Natl Cancer Inst. 2024 Mar 7;116(3):434-444. doi: 10.1093/jnci/djad210.

DOI:10.1093/jnci/djad210

PMID:38013591

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10919343/

Abstract

BACKGROUND

Studies of sleep and prostate cancer are almost entirely based on self-report, with limited research using actigraphy. Our goal was to evaluate actigraphy-measured sleep and prostate cancer and to expand on findings from prior studies of self-reported sleep.

METHODS

We prospectively examined 34 260 men without a history of prostate cancer in the UK Biobank. Sleep characteristics were measured over 7 days using actigraphy. We calculated sleep duration, onset, midpoint, wake-up time, social jetlag (difference in weekend-weekday sleep midpoints), sleep efficiency (percentage of time spent asleep between onset and wake-up time), and wakefulness after sleep onset. Cox proportional hazards models were used to estimate covariate-adjusted hazards ratios (HRs) and 95% confidence intervals (CIs).

RESULTS

Over 7.6 years, 1152 men were diagnosed with prostate cancer. Sleep duration was not associated with prostate cancer risk. Sleep midpoint earlier than 4:00 am was not associated with prostate cancer risk, though sleep midpoint of 5:00 am or later was suggestively associated with lower prostate cancer risk but had limited precision (earlier than 4:00 am vs 4:00-4:59 am HR = 1.00, 95% CI = 0.87 to 1.16; 5:00 am or later vs 4:00-4:59 am HR = 0.79, 95% CI = 0.57 to 1.10). Social jetlag was not associated with greater prostate cancer risk (1 to <2 hours vs <1 hour HR = 1.06, 95% CI = 0.89 to 1.25; ≥2 hours vs <1 hour HR = 0.90, 95% CI = 0.65 to 1.26). Compared with men who averaged less than 30 minutes of wakefulness after sleep onset per day, men with 60 minutes or more had a higher risk of prostate cancer (HR = 1.20, 95% CI = 1.00 to 1.43).

CONCLUSIONS

Of the sleep characteristics studied, higher wakefulness after sleep onset-a measure of poor sleep quality-was associated with greater prostate cancer risk. Replication of our findings between wakefulness after sleep onset and prostate cancer are warranted.

摘要

背景

关于睡眠与前列腺癌的研究几乎完全基于自我报告，使用活动记录仪进行的研究有限。我们的目标是评估活动记录仪测量的睡眠与前列腺癌，并扩展先前关于自我报告睡眠的研究结果。

方法

我们前瞻性地检查了英国生物库中 34260 名没有前列腺癌病史的男性。使用活动记录仪在 7 天内测量睡眠特征。我们计算了睡眠持续时间、开始时间、中点、醒来时间、社交时差（周末-工作日睡眠中点的差异）、睡眠效率（入睡时间与醒来时间之间的睡眠时间百分比）和睡眠后清醒度。使用 Cox 比例风险模型估计协变量调整后的风险比（HR）和 95%置信区间（CI）。

结果

在 7.6 年内，有 1152 名男性被诊断患有前列腺癌。睡眠持续时间与前列腺癌风险无关。凌晨 4 点之前的睡眠中点与前列腺癌风险无关，但凌晨 5 点或更晚的睡眠中点与前列腺癌风险呈负相关，但精确度有限（凌晨 4 点之前 vs 凌晨 4:00-4:59 am HR=1.00，95%CI=0.87 至 1.16；凌晨 5 点或更晚 vs 凌晨 4:00-4:59 am HR=0.79，95%CI=0.57 至 1.10）。社交时差与更大的前列腺癌风险无关（1 至<2 小时与<1 小时 HR=1.06，95%CI=0.89 至 1.25；≥2 小时与<1 小时 HR=0.90，95%CI=0.65 至 1.26）。与每天平均少于 30 分钟睡眠后清醒度的男性相比，有 60 分钟或更长时间睡眠后清醒度的男性患前列腺癌的风险更高（HR=1.20，95%CI=1.00 至 1.43）。