DC-T 细胞轴是非小细胞肺癌治疗的有效靶点。
The DC-T cell axis is an effective target for the treatment of non-small cell lung cancer.
机构信息
Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
出版信息
Immun Inflamm Dis. 2023 Nov;11(11):e1099. doi: 10.1002/iid3.1099.
The dendritic cell (DC)-T cell axis is a bridge that connects innate and adaptive immunities. The initial immune response against tumors is mainly induced by mature antigen-presenting DCs. Enhancing the crosstalk between DCs and T cells may be an effective approach to improve the immune response to non-small cell lung cancer (NSCLC). In this article, a review was made of the interaction between DCs and T cells in the treatment of NSCLC and how this interaction affects the treatment outcome.
树突状细胞 (DC)-T 细胞轴是连接先天免疫和适应性免疫的桥梁。针对肿瘤的初始免疫反应主要由成熟的抗原呈递 DC 诱导。增强 DC 与 T 细胞之间的串扰可能是提高非小细胞肺癌 (NSCLC) 免疫反应的有效方法。本文综述了 DC 与 T 细胞在 NSCLC 治疗中的相互作用以及这种相互作用如何影响治疗效果。
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