酒精性泡沫样变性：一种在尸检时诊断出的酒精性肝病的不寻常表现。

Alcoholic foamy degeneration: an unusual presentation of the alcoholic liver disease diagnosed on autopsy.

作者信息

Joshi Rashmi, Parkhi Mayur, Gupta Anjali, Susngi Terence, Kumar Ashwani, Dhibar Deba Prasad, Mitra Suvradeep

机构信息

Post Graduate Institute of Medical Education and Research, Department of Histopathology, Chandigarh, India.

Post Graduate Institute of Medical Education and Research, Department of Internal Medicine, Chandigarh, India.

出版信息

Autops Case Rep. 2023 Oct 11;13:e2023446. doi: 10.4322/acr.2023.446. eCollection 2023.

DOI:10.4322/acr.2023.446

PMID:38034523

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10688259/

Abstract

Alcoholic foamy degeneration (AFD) is an uncommon presentation of alcoholic liver disease (ALD) with characteristic histologic findings of foamy-looking hepatocytes due to the presence of abundant microvesicles of fat within the cytoplasm predominantly in perivenular and midzonal regions without inflammation and fibrosis. It is underdiagnosed as the patients quickly recover after alcoholic abstinence and are rarely caught on biopsies. AFD has better prognosis than alcoholic hepatitis, and the injury mechanism is different, warranting a different diagnosis. We present an uncommon case of AFD incidentally diagnosed during autopsy in a chronic alcoholic and diabetic man.

摘要

酒精性泡沫样变性（AFD）是酒精性肝病（ALD）的一种不常见表现，具有特征性的组织学表现，即由于细胞质内存在大量微脂肪泡，主要在肝小叶中央静脉周围和中间带区域，肝细胞呈泡沫样外观，且无炎症和纤维化。由于患者在戒酒后很快康复，活检时很少被发现，因此AFD常被漏诊。AFD的预后比酒精性肝炎好，其损伤机制不同，需要不同的诊断方法。我们报告一例在一名慢性酒精中毒和糖尿病男性尸检时偶然诊断出的AFD罕见病例。