载脂蛋白E的E2/E3和E3/E4基因型与高血压患者患糖尿病的较高风险相关。

E2/E3 and E3/E4 Genotypes of the Apolipoprotein E are Associated with Higher Risk of Diabetes Mellitus in Patients with Hypertension.

作者信息

Han Wendao, Xiong Nating, Zhong Renkai, Pan Zhongyi

机构信息

Department of Blood Transfusion, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, Meizhou, People's Republic of China.

Center for Precision Medicine, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, Meizhou, People's Republic of China.

出版信息

Int J Gen Med. 2023 Nov 24;16:5579-5586. doi: 10.2147/IJGM.S438008. eCollection 2023.

DOI:10.2147/IJGM.S438008

PMID:38034897

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10683662/

Abstract

OBJECTIVE

Apolipoprotein E (APOE) plays an important role in the lipid metabolism. polymorphisms have been implicated in susceptibility to diabetes mellitus (DM). However, the association between polymorphisms and the risk of DM among the hypertensive patients remains unclear. Our study aimed to evaluate this relationship to provide clues for further developing DM in hypertensive patients.

METHODS

The study included 808 hypertensive patients with DM and 1226 hypertensive patients without DM as controls. The 388T>C (rs429358) and 526C>T (rs7412) polymorphisms were genotyped by polymerase chain reaction (PCR) - microarray. Differences in genotypes between subjects and controls were compared. To analyze the relationship between genotypes and DM risk, multiple logistic regression analysis was performed after adjusting for gender, age, smoking history, and drinking history.

RESULTS

The E2/E4, E3/E3 genotype and ε2, ε3 allele frequency had significant difference between DM patients and controls (<0.05). The DM patients with ɛ4 allele had lower level in high-density lipoprotein cholesterol (HDL-C) and higher level in apolipoprotein B (ApoB) than those with ɛ2 allele. The results of logistic regression analysis indicated that the genotype of E2/E3 with adjusted OR=1.350 (95% Cl=1.009-1.806, =0.043) and E3/E4 with adjusted OR=1.325 (95% Cl=1.034-1699, =0.026) may be independent risk factors for DM.

CONCLUSION

E2/E3 and E3/E4 genotypes may be risk factors for developing diabetes mellitus in hypertensive patients.

摘要

目的

载脂蛋白E（APOE）在脂质代谢中起重要作用。其基因多态性与糖尿病（DM）易感性有关。然而，高血压患者中该基因多态性与DM风险之间的关联仍不清楚。我们的研究旨在评估这种关系，为高血压患者DM的进一步发展提供线索。

方法

该研究纳入808例患有DM的高血压患者和1226例未患DM的高血压患者作为对照。采用聚合酶链反应（PCR）-微阵列法对388T>C（rs429358）和526C>T（rs7412）基因多态性进行基因分型。比较研究对象与对照组之间基因型的差异。为分析基因型与DM风险之间的关系，在调整性别、年龄、吸烟史和饮酒史后进行多因素logistic回归分析。

结果

DM患者与对照组之间的E2/E4、E3/E3基因型以及ε2、ε3等位基因频率存在显著差异（<0.05）。携带ɛ4等位基因的DM患者高密度脂蛋白胆固醇（HDL-C）水平低于携带ɛ2等位基因的患者，而载脂蛋白B（ApoB）水平高于携带ɛ2等位基因的患者。logistic回归分析结果表明，调整后的OR=1.350（95%CI=1.009-1.806，P=0.043）的E2/E3基因型和调整后的OR=1.325（95%CI=1.034-1.699，P=0.026）的E3/E4基因型可能是DM的独立危险因素。