酰胺N-C键活化：酰基和脱羰偶联的图形概述
Amide N-C Bond Activation: A Graphical Overview of Acyl and Decarbonylative Coupling.
作者信息
Liu Chengwei, Szostak Michal
机构信息
Department of Chemistry, Shanghai University, 99 Shangda Road, Shanghai 200444, China.
Department of Chemistry, Rutgers University, 73 Warren Street, Newark, NJ 07102, USA.
出版信息
SynOpen. 2023 Feb;7(1):88-101. doi: 10.1055/a-2035-6733. Epub 2023 Mar 6.
Abstract
This Graphical Review provides an overview of amide bond activation achieved by selective oxidative addition of the N-C(O) acyl bond to transition metals and nucleophilic acyl addition, resulting in acyl and decarbonylative coupling together with key mechanistic details pertaining to amide bond distortion underlying this reactivity manifold.
摘要
本图形综述概述了通过将N-C(O)酰基键选择性氧化加成到过渡金属上以及亲核酰基加成实现的酰胺键活化，从而导致酰基和脱羰基偶联，以及与这种反应多样性背后的酰胺键扭曲相关的关键机理细节。
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