人腺病毒12型早期区域2b编码基因的核苷酸序列。

Nucleotide sequence of the genes encoded in early region 2b of human adenovirus type 12.

作者信息

Shu L M, Hong J S, Wei Y F, Engler J A

出版信息

Gene. 1986;46(2-3):187-95. doi: 10.1016/0378-1119(86)90403-8.

Abstract

The nucleotide (nt) sequence of a cloned DNA segment containing the early 2b region of the class A adenovirus Ad12 has been determined. When compared to the corresponding region of Ad2 or Ad7, there is a high degree of nt and predicted amino acid (aa) sequence homology within the r-strand regions that encode the preterminal protein and the viral DNA polymerase. A gene coding region comparable to the Mr 13,600 gene product found in Ad2 can be identified; this hypothetical gene product shares 30% aa homology with its Ad2 counterpart and has a very similar hydropathy profile.

摘要

已确定包含A类腺病毒Ad12早期2b区域的克隆DNA片段的核苷酸（nt）序列。与Ad2或Ad7的相应区域相比，在编码末端前体蛋白和病毒DNA聚合酶的r链区域内，核苷酸和预测的氨基酸（aa）序列具有高度同源性。可以鉴定出一个与Ad2中发现的13,600 Mr基因产物相当的基因编码区域；该假设的基因产物与其Ad2对应物具有30%的氨基酸同源性，并且具有非常相似的亲水性图谱。