Gullo L, Priori P, Baldoni F, Mattioli G
Gut. 1986 Dec;27(12):1479-83. doi: 10.1136/gut.27.12.1479.
The effect of met-enkephalin on pure exocrine pancreatic secretion was studied in five subjects with external transduodenal drainage of the main pancreatic duct carried out after biliary tract surgery. Intravenous infusion of a low dose of met-enkephalin (0.15 micrograms/kg/h) during submaximal pancreatic stimulation with secretin (25 ng/kg/h) and cerulein (10 ng/kg/h) significantly increased pancreatic outputs. Bicarbonate secretion increased 50% above control values, a more marked effect than the increase in enzyme secretion (maximal rise averaged 22%). The effect of the peptide was rapid, persisted for the duration of met-enkephalin infusion and then tended gradually to diminish.
在五名接受胆道手术后经十二指肠外引流主胰管的受试者中,研究了甲硫氨酸脑啡肽对纯外分泌性胰腺分泌的影响。在用促胰液素(25 ng/kg/h)和雨蛙素(10 ng/kg/h)进行次最大刺激胰腺期间,静脉输注低剂量甲硫氨酸脑啡肽(0.15微克/千克/小时)可显著增加胰腺分泌量。碳酸氢盐分泌比对照值增加50%,其作用比酶分泌增加更显著(最大增幅平均为22%)。该肽的作用迅速,在甲硫氨酸脑啡肽输注期间持续存在,然后逐渐趋于减弱。